All Phenotypes Il22<tm1Flv> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il22^tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3761615

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il22^tm1Flv/Il22^tm1Flv	B6.Cg-Il22^tm1Flv	MGI:3761616
hm2	Il22^tm1Flv/Il22^tm1Flv	involves: 129/Sv * C57BL/6	MGI:5446698
ht3	Il22^tm1Flv/Il22⁺	B6.Cg-Il22^tm1Flv	MGI:3761617
cx4	Il22^tm1Flv/Il22^tm1Flv Il22ra2^tm2Vlcg/Il22ra2^tm2Vlcg	involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:5446697
cx5	Il17a^tm1Yiw/Il17a^tm1Yiw Il22^tm1Flv/Il22^tm1Flv	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3761618
cx6	Apc^Min/Apc⁺ Il22^tm1Flv/Il22^tm1Flv	involves: 129/Sv * C57BL/6 * C57BL/6J	MGI:5446700

Allelic Composition	Il22^tm1Flv/Il22^tm1Flv
Genetic Background	B6.Cg-Il22^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22^tm1Flv mutation (0 available); any Il22 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to endotoxin shock ( J:126103 )

• following injection concanavalin, 32% (at 10 ug/g) and 100% (at 20 ug/g) of mice die whereas no wild-type mice exhibit any outward signs of morbidity

• however, mice have normal innate and adaptive immune responses to Listeria monocytogenes infection

liver inflammation ( J:126103 )

• mice exhibit more extensive liver damage in response to concanavalin-mediated hepatitis

• however, suppression of IFN-gamma-induced inflammation abolishes the excessive liver damage

homeostasis/metabolism

increased circulating alanine transaminase level ( J:126103 )

• following injection of concanavalin

• however, levels are normal following injection of phosphate buffered saline

increased circulating aspartate transaminase level ( J:126103 )

• following injection of concanavalin

• however, levels are normal following injection of phosphate buffered saline

increased physiological sensitivity to xenobiotic ( J:126103 )

• following injection of concanavalin, mice develop more lesions than wild-type mice and extensive lesions on the perimeter of the liver lobes

• however, suppression of IFN-gamma-induced inflammation abolishes the excessive liver damage

liver/biliary system

liver inflammation ( J:126103 )

• mice exhibit more extensive liver damage in response to concanavalin-mediated hepatitis

• however, suppression of IFN-gamma-induced inflammation abolishes the excessive liver damage

Allelic Composition	Il22^tm1Flv/Il22^tm1Flv
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22^tm1Flv mutation (0 available); any Il22 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:189217 )

• tumor numbers in a colitis associated colon cancer model are increased compared to wild-type controls

digestive/alimentary system

increased susceptibility to induced colitis ( J:189217 )

• increased disease and inflammation following DSS treatment

immune system

increased susceptibility to induced colitis ( J:189217 )

• increased disease and inflammation following DSS treatment

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:189217 )

• tumor numbers in a colitis associated colon cancer model are increased compared to wild-type controls

Allelic Composition	Il22^tm1Flv/Il22⁺
Genetic Background	B6.Cg-Il22^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22^tm1Flv mutation (0 available); any Il22 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:126103 )

• following injection of concanavalin, mice develop more lesions than wild-type mice but fewer than homozygous mice

immune system

increased susceptibility to endotoxin shock ( J:126103 )

• following injection concanavalin, 25% (at 10 ug/g) and 100% (at 20 ug/g) of mice die whereas no wild-type mice exhibit any outward signs of morbidity

Allelic Composition	Il22^tm1Flv/Il22^tm1Flv Il22ra2^tm2Vlcg/Il22ra2^tm2Vlcg
Genetic Background	involves: 129 * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il22ra2^tm2Vlcg mutation (0 available); any Il22ra2 mutation (22 available)
Il22^tm1Flv mutation (0 available); any Il22 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:189217 )

• tumor numbers in a colitis associated colon cancer model are decreased compared to mice homozygous for Il22ra2^tm2Vlcg alone but increased compared to wild-type controls

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:189217 )

• tumor numbers in a colitis associated colon cancer model are decreased compared to mice homozygous for Il22ra2^tm2Vlcg alone but increased compared to wild-type controls

Allelic Composition	Il17a^tm1Yiw/Il17a^tm1Yiw Il22^tm1Flv/Il22^tm1Flv
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17a^tm1Yiw mutation (0 available); any Il17a mutation (23 available)
Il22^tm1Flv mutation (0 available); any Il22 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:126103 )

• concanavalin-induced liver damage is similar to that in Il22^tm2Flv single homozygous mice

Allelic Composition	Apc^Min/Apc⁺ Il22^tm1Flv/Il22^tm1Flv
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Il22^tm1Flv mutation (0 available); any Il22 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased alimentary system tumor incidence ( J:189217 )

• decrease in tumor numbers in the small intestine and colon compared to mice heterozygous for Apc^Min alone

digestive/alimentary system

decreased alimentary system tumor incidence ( J:189217 )

• decrease in tumor numbers in the small intestine and colon compared to mice heterozygous for Apc^Min alone

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