Analysis Tools
immune system
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• B cell size is increased
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• early B cell differentiation is partially blocked
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• when cultured for 5 days in the present of LPS and IL4, more B cells switch to the IgG1+ isotype than in wild-type cells
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• the number of immature B cells in the peritoneum is decreased relative to the number in wild-type mice
• the number of immature B cells is reduced (4.8+/-0.7x106 compared to 7.7+/-0.8x106 in wild-type spleens)
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• the number of B-1a and B-1b cells in the peritoneal cavity is decreased relative to in wild-type mice (0.3+/-0.2 x106 compared to 1.4+/-0.3 x106 in wild-type mice)
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• unlike in wild-type mice, B cells accumulate in secondary lymph nodes (111.1+/-17.3x106 compared to 46.7+/-4.8x106 in wild-type spleens)
• Peyer's patches have a 3-fold increase in B cells rich in IgG1-expressing B cells compared to in wild-type mice
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• the proportion of marginal zone and follicular B cells is increased by 2- to 3-fold compared to in wild-type mice
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• spleen structure is disorganized such that the distinct B cell and T cell zones of the follicle are not uniform as in wild-type spleens
• the B cell region located outside of the marginal zone is larger than in wild-type mice
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• unlike in wild-type mice the marginal zone is disordered and disorganized
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• the proportion of marginal zone and follicular B cells is increased by 2- to 3-fold compared to in wild-type mice
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• B cell survival in culture is increased relative to that of wild-type B cells by 2-fold after 4 days and B cells respond better to BAFF treatment than do wild-type B cells
• however, proliferation is normal
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• mice exhibit an increase in PNA+Fas+ B cells in Peyer's patch compared to in wild-type mice indicative of germinal center B cells
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• lymph nodes are enlarged
• secondary lymph nodes are enlarged as early as 4 weeks of age
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• in response to a NP-CG challenge, mice produce fewer IgM and IgG3 isotypes, more IgG1 and IgG2a isotypes, and more Ig-lambda antibodies compared to wild-type mice
• in response to a KLH challenge, mice produce more IgG1 antibodies than wild-type micein response to a KLH challenge, mice produce more IgG1 antibodies than wild-type mice
• however, in response to a NP-Ficoll challenge, mice produce similar levels of NP-specific IgM and IgG3 antibodies as wild-type mice
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hematopoietic system
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• B cell size is increased
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• early B cell differentiation is partially blocked
|
|
• when cultured for 5 days in the present of LPS and IL4, more B cells switch to the IgG1+ isotype than in wild-type cells
|
|
• the number of immature B cells in the peritoneum is decreased relative to the number in wild-type mice
• the number of immature B cells is reduced (4.8+/-0.7x106 compared to 7.7+/-0.8x106 in wild-type spleens)
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• the number of B-1a and B-1b cells in the peritoneal cavity is decreased relative to in wild-type mice (0.3+/-0.2 x106 compared to 1.4+/-0.3 x106 in wild-type mice)
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• unlike in wild-type mice, B cells accumulate in secondary lymph nodes (111.1+/-17.3x106 compared to 46.7+/-4.8x106 in wild-type spleens)
• Peyer's patches have a 3-fold increase in B cells rich in IgG1-expressing B cells compared to in wild-type mice
|
|
• the proportion of marginal zone and follicular B cells is increased by 2- to 3-fold compared to in wild-type mice
|
|
• spleen structure is disorganized such that the distinct B cell and T cell zones of the follicle are not uniform as in wild-type spleens
• the B cell region located outside of the marginal zone is larger than in wild-type mice
|
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• unlike in wild-type mice the marginal zone is disordered and disorganized
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• the proportion of marginal zone and follicular B cells is increased by 2- to 3-fold compared to in wild-type mice
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• B cell survival in culture is increased relative to that of wild-type B cells by 2-fold after 4 days and B cells respond better to BAFF treatment than do wild-type B cells
• however, proliferation is normal
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growth/size/body
