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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CD207-cre)1Dhka
transgene insertion 1, Daniel H Kaplan
MGI:3761645
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Epcamtm1.1Mcu/Epcamtm1.1Mcu
Tg(CD207-cre)1Dhka/0 		involves: 129 * C57BL/6 * C57BL/6J * SJL/J MGI:5318400
cn2
 		Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761678
cn3
 		B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761679
cn4
 		B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761680
cn5
 		Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761681
cn6
 		B9d2/Tgfb1tm1Flv/B9d2+
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761682


Genotype
MGI:5318400
cn1
Allelic
Composition		 Epcamtm1.1Mcu/Epcamtm1.1Mcu
Tg(CD207-cre)1Dhka/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epcamtm1.1Mcu mutation (0 available); any Epcam mutation (33 available)
Tg(CD207-cre)1Dhka mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal Langerhans cell morphology ( J:182665 )
• about a 2 fold increase in frequency in epidermal sheets compared to wild-type controls
• cells are larger and have longer, more delicate dendrites
abnormal Langerhans cell physiology ( J:182665 )
• impaired migration of Langerhans cells from skin explants
• at 36 h, but not at 18 or 48 h, after application of TNCB to the ear skin the number of activated Langerhans cells is increased about 2 fold indicating a defect in the ability of these cells to exit the epidermis
• strikingly fewer Langerhans cells are found in the skin draining lymph nodes at 96 and 120 h after hapten application
increased susceptibility to type IV hypersensitivity reaction ( J:182665 )
• ear swelling is increased about 2 fold and the duration of the response is prolonged following treatment and challenge with 2,4-dinitrofluorobenzene

hematopoietic system
abnormal Langerhans cell morphology ( J:182665 )
• about a 2 fold increase in frequency in epidermal sheets compared to wild-type controls
• cells are larger and have longer, more delicate dendrites

cellular
abnormal cell migration ( J:182665 )
• impaired migration of Langerhans cells from skin explants
• at 36 h, but not at 18 or 48 h, after application of TNCB to the ear skin the number of activated Langerhans cells is increased about 2 fold indicating a defect in the ability of these cells to exit the epidermis
• strikingly fewer Langerhans cells are found in the skin draining lymph nodes at 96 and 120 h after hapten application




Genotype
MGI:3761678
cn2
Allelic
Composition		 Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD207-cre)1Dhka mutation (1 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.59% of total epidermal cells compared to 0.46% to 0.89% in wild-type mice)
• the ratio of Langerhans cells in the epidermis increases with age

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.59% of total epidermal cells compared to 0.46% to 0.89% in wild-type mice)
• the ratio of Langerhans cells in the epidermis increases with age




Genotype
MGI:3761679
cn3
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tg(CD207-cre)1Dhka mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters




Genotype
MGI:3761680
cn4
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(CD207-cre)1Dhka mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters




Genotype
MGI:3761681
cn5
Allelic
Composition		 Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tg(CD207-cre)1Dhka mutation (1 available)
Tgfb1tm2Flv mutation (0 available); any Tgfb1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice




Genotype
MGI:3761682
cn6
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2+
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(CD207-cre)1Dhka mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory