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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcnatm1Jcbs
targeted mutation 1, Heinz Jacobs
MGI:3761720
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pcnatm1Jcbs/Pcnatm1Jcbs involves: 129P2/OlaHsd MGI:4429641
hm2
 		Pcnatm1Jcbs/Pcnatm1Jcbs involves: 129P2/OlaHsd * C57BL/6 MGI:3761723
cx3
 		Msh2tm1Htr/Msh2tm1Htr
Pcnatm1Jcbs/Pcnatm1Jcbs 		involves: 129P2/OlaHsd MGI:4429640
cx4
 		Pcnatm1Jcbs/Pcnatm1Jcbs
Ungtm1Tld/Ungtm1Tld 		involves: 129P2/OlaHsd MGI:4429642


Genotype
MGI:4429641
hm1
Allelic
Composition		 Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnatm1Jcbs mutation (0 available); any Pcna mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal somatic hypermutation frequency ( J:155454 , J:177630 )
• mice exhibit a 36% reduction in total mutation frequency in germinal center B cell compared with wild-type mice (J:155454)
• strongly reduced number of A/T mutations in germinal center B cells (J:177630)

immune system
abnormal somatic hypermutation frequency ( J:155454 , J:177630 )
• mice exhibit a 36% reduction in total mutation frequency in germinal center B cell compared with wild-type mice (J:155454)
• strongly reduced number of A/T mutations in germinal center B cells (J:177630)




Genotype
MGI:3761723
hm2
Allelic
Composition		 Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnatm1Jcbs mutation (0 available); any Pcna mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:125916 )
• homozygous pups only make up 5% of litters instead of the expected 25%

reproductive system
absent germ cells ( J:125916 )
• complete lack of germ cells in the testes or ovaries
infertility ( J:125916 )
• both female and male mice are infertile

immune system
abnormal somatic hypermutation frequency ( J:125916 )
• 10 fold reduction of transitions and transversions of template A/T
• compensatory increase of mutations on template G/C

hematopoietic system
abnormal somatic hypermutation frequency ( J:125916 )
• 10 fold reduction of transitions and transversions of template A/T
• compensatory increase of mutations on template G/C

cellular
absent germ cells ( J:125916 )
• complete lack of germ cells in the testes or ovaries




Genotype
MGI:4429640
cx3
Allelic
Composition		 Msh2tm1Htr/Msh2tm1Htr
Pcnatm1Jcbs/Pcnatm1Jcbs
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Pcnatm1Jcbs mutation (0 available); any Pcna mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Msh2tm1Htr homozygotes

hematopoietic system
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Msh2tm1Htr homozygotes




Genotype
MGI:4429642
cx4
Allelic
Composition		 Pcnatm1Jcbs/Pcnatm1Jcbs
Ungtm1Tld/Ungtm1Tld
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnatm1Jcbs mutation (0 available); any Pcna mutation (19 available)
Ungtm1Tld mutation (0 available); any Ung mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcnatm1Jcbs homozygotes

immune system
abnormal somatic hypermutation frequency ( J:155454 )
• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcnatm1Jcbs homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory