All Phenotypes Ntsr1<tm2Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ntsr1^tm2Dgen
targeted mutation 1, Deltagen
MGI:3761722

Summary

2 genotypes

Allelic Composition	Ntsr1^tm2Dgen/Ntsr1^tm2Dgen
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntsr1^tm2Dgen mutation (0 available); any Ntsr1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:126020 )

• mice do not exhibit a decrease in coordination following treatment with neurotensin 2 unlike wild-type mice

• mice fail to exhibit an increase in latency during a hot plate test following treatment with neurotensin or neurotensin 2 unlike wild-type mice

digestive/alimentary system

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit a decrease in colonic propulsion following treatment with neurotensin 2 unlike wild-type mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

homeostasis/metabolism

decreased body temperature ( J:126020 )

• following injection of 1 ug neurotensin or 1 mg/kg neurotensin 2, mice fail to exhibit a hypothermic response as wild-type mice do

muscle

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit a decrease in colonic propulsion following treatment with neurotensin 2 unlike wild-type mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

Allelic Composition	Ntsr1^tm2Dgen/Ntsr1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntsr1^tm2Dgen mutation (0 available); any Ntsr1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit an intermediate decrease in colonic propulsion following treatment with neurotensin 2 compared to wild-type and homozygous mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

muscle

intestinal hypoperistalsis ( J:126020 )

• mice do not exhibit an intermediate decrease in colonic propulsion following treatment with neurotensin 2 compared to wild-type and homozygous mice

• however, mice are still susceptible to clonidine induced hypoperistalsis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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