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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx3tm1Itan
targeted mutation 1, Ichior Taniuchi
MGI:3761811
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 MGI:3776115
cn2
 		Runx3tm1Itan/Runx3+
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:7485833
cn3
 		Runx3tm1Itan/Runx3tm1Itan
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:7485836
cn4
 		Runx1tm1Toku/Runx1+
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3776110
cn5
 		Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3761834
cn6
 		Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3+
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3776111
cn7
 		Runx1tm1Tani/Runx1tm1Tani
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/? 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3763114
cn8
 		Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3776109


Genotype
MGI:3776115
cn1
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Runx1tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD4-positive, alpha-beta T cell number ( J:131081 )
• mice have predominance of CD4+CD8- T cells in thymus and periphery, indicating that MHC I-restricted cells are forced to differentiate into CD4+CD8- T cells
abnormal interferon secretion ( J:131081 )
• after TCR stimulation, interferon gamma production is absent from class I-restricted CD4+CD8- cells

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:131081 )
• mice have predominance of CD4+CD8- T cells in thymus and periphery, indicating that MHC I-restricted cells are forced to differentiate into CD4+CD8- T cells




Genotype
MGI:7485833
cn2
Allelic
Composition		 Runx3tm1Itan/Runx3+
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Runx3

mortality/aging
increased tumor-free survival time ( J:319454 )
• increased lifespan compared to mutant mice wild-type for Runx3

skeleton
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Runx3




Genotype
MGI:7485836
cn3
Allelic
Composition		 Runx3tm1Itan/Runx3tm1Itan
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:319454 )
• many die before osteosarcoma formation




Genotype
MGI:3776110
cn4
Allelic
Composition		 Runx1tm1Toku/Runx1+
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:131081 )
• significantly lower than in controls

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:131081 )
• significantly lower than in controls




Genotype
MGI:3761834
cn5
Allelic
Composition		 Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha beta T cell morphology ( J:125953 )
• subset of CD8-positive T cells in the periphery also express intermediate levels of CD4
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125953 )
• very few CD8-positive T cells are found in the thymus
• level of mature CD8-postive T cells in the thymus reduced by 25%
decreased CD8-positive, alpha-beta T cell number ( J:131081 )
• CD8+ T cell absolute numbers are decreased
increased IgA level ( J:125953 )
• slighlty higher levels in the serum
lung inflammation ( J:125953 )
• a mild asthma-like disease occurs in one third of the mice with lymphocytes and eosinophils infiltrating the bronchioles and perivascular space

respiratory system
lung inflammation ( J:125953 )
• a mild asthma-like disease occurs in one third of the mice with lymphocytes and eosinophils infiltrating the bronchioles and perivascular space

hematopoietic system
abnormal CD8-positive, alpha beta T cell morphology ( J:125953 )
• subset of CD8-positive T cells in the periphery also express intermediate levels of CD4
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125953 )
• very few CD8-positive T cells are found in the thymus
• level of mature CD8-postive T cells in the thymus reduced by 25%
decreased CD8-positive, alpha-beta T cell number ( J:131081 )
• CD8+ T cell absolute numbers are decreased
increased IgA level ( J:125953 )
• slighlty higher levels in the serum




Genotype
MGI:3776111
cn6
Allelic
Composition		 Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:131081 )
• significantly lower than in controls

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:131081 )
• significantly lower than in controls




Genotype
MGI:3763114
cn7
Allelic
Composition		 Runx1tm1Tani/Runx1tm1Tani
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Tani mutation (1 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:125959 )
• very few CD8 T cells found in the thymus
• the CD8 T cells that found have escaped Cre excession

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:125959 )
• very few CD8 T cells found in the thymus
• the CD8 T cells that found have escaped Cre excession




Genotype
MGI:3776109
cn8
Allelic
Composition		 Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3tm1Itan mutation (1 available); any Runx3 mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:131081 )
• numbers are lower than in controls
decreased CD8-positive, alpha-beta T cell number ( J:131081 )
• mice show a marked reduction in CD8+ T cells

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:131081 )
• numbers are lower than in controls
decreased CD8-positive, alpha-beta T cell number ( J:131081 )
• mice show a marked reduction in CD8+ T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory