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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cbfbtm1Itan
targeted mutation 1, Ichiro Taniuchi
MGI:3761812
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cbfbtm1Itan/Cbfbtm1Itan
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd MGI:3761838
cn2
 		Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7b+
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3821708
cn3
 		Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7btm1.2Litt
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3821709
cn4
 		Cbfbtm1Itan/Cbfbtm1Itan
Tg(KRT14-cre)1Amc/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:6455789
cn5
 		Cbfbtm1Itan/Cbfbtm1Itan
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:4452099
cn6
 		Cbfbtm1Itan/Cbfbtm1Itan
Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N MGI:4452098


Genotype
MGI:3761838
cn1
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:125953 )
• 2 fold decrease in total number
abnormal T-helper 1 cell differentiation ( J:125953 )
• slightly increased levels of the Th-2 cytokine IL-4 are produced when nave T cells are activated in vitro
• a small subset of T cells produce both IL-4 and IFN-gamma when nave T cells are cultured under Th1 polarizing conditions
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125953 )
• very few CD8-positive T cells are found in the thymus
abnormal double-positive T cell morphology ( J:125953 )
• increase in DP T cell due to reduced ability of T cell precursors to mature past double positive stage

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:125953 )
• 2 fold decrease in total number
abnormal T-helper 1 cell differentiation ( J:125953 )
• slightly increased levels of the Th-2 cytokine IL-4 are produced when nave T cells are activated in vitro
• a small subset of T cells produce both IL-4 and IFN-gamma when nave T cells are cultured under Th1 polarizing conditions
abnormal CD8-positive, alpha-beta T cell differentiation ( J:125953 )
• very few CD8-positive T cells are found in the thymus
abnormal double-positive T cell morphology ( J:125953 )
• increase in DP T cell due to reduced ability of T cell precursors to mature past double positive stage

endocrine/exocrine glands




Genotype
MGI:3821708
cn2
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7b+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced

hematopoietic system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced




Genotype
MGI:3821709
cn3
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7btm1.2Litt
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7btm1.2Litt mutation (1 available); any Zbtb7b mutation (26 available)
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced between 5-10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced

immune system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced between 5-10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced




Genotype
MGI:6455789
cn4
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Tg(KRT14-cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal palate development ( J:277246 )
• at E15.0 in some mice contact between primary and secondary palates is seen but mesenchymal confluence is not yet present and in others contact is absent
• at E16.0, contact between primary and secondary palates is absent in all mice
• at E15.0 there is partial contact but no fusion of the epithelium at the boundary between the primary and secondary palates and proliferation is increased and apoptosis decreased in the epithelium
submucous cleft palate ( J:277246 )
• partial submucous cleft with retained epithelial remnants at the anterior-most region of the secondary palate at P0
anterior cleft palate ( J:277246 )
• anterior cleft between the primary and secondary palates at P0 and P50 with the secondary palate failing to make contact with the primary palate and the nasal septum
• anterior cleft is seen in all mice at P0 and increases in size by P50
• in culture treatment with TGFB3 beads or folic acid rescues palatal cleft in many explants

digestive/alimentary system
abnormal palate development ( J:277246 )
• at E15.0 in some mice contact between primary and secondary palates is seen but mesenchymal confluence is not yet present and in others contact is absent
• at E16.0, contact between primary and secondary palates is absent in all mice
• at E15.0 there is partial contact but no fusion of the epithelium at the boundary between the primary and secondary palates and proliferation is increased and apoptosis decreased in the epithelium
submucous cleft palate ( J:277246 )
• partial submucous cleft with retained epithelial remnants at the anterior-most region of the secondary palate at P0
anterior cleft palate ( J:277246 )
• anterior cleft between the primary and secondary palates at P0 and P50 with the secondary palate failing to make contact with the primary palate and the nasal septum
• anterior cleft is seen in all mice at P0 and increases in size by P50
• in culture treatment with TGFB3 beads or folic acid rescues palatal cleft in many explants

growth/size/body
abnormal palate development ( J:277246 )
• at E15.0 in some mice contact between primary and secondary palates is seen but mesenchymal confluence is not yet present and in others contact is absent
• at E16.0, contact between primary and secondary palates is absent in all mice
• at E15.0 there is partial contact but no fusion of the epithelium at the boundary between the primary and secondary palates and proliferation is increased and apoptosis decreased in the epithelium
submucous cleft palate ( J:277246 )
• partial submucous cleft with retained epithelial remnants at the anterior-most region of the secondary palate at P0
anterior cleft palate ( J:277246 )
• anterior cleft between the primary and secondary palates at P0 and P50 with the secondary palate failing to make contact with the primary palate and the nasal septum
• anterior cleft is seen in all mice at P0 and increases in size by P50
• in culture treatment with TGFB3 beads or folic acid rescues palatal cleft in many explants




Genotype
MGI:4452099
cn5
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:125953 )
• slight reduction in number of mature T cells in the thymus
• Cbfbeta protein is detectable in T cells of the thymus but not the periphery
abnormal T-helper 1 cell differentiation ( J:125953 )
• significant levels of the Th-2 cytokine IL-4 are produced when nave T cells are activated in vitro
• some T cells produce both IL-4 and IFN-gamma when nave T cells are cultured under Th1 polarizing conditions
abnormal CD8-positive, alpha beta T cell morphology ( J:125953 , J:158962 )
• vast majority of CD8-positive T cells in the periphery also express CD4 (J:125953)
• CD8+ T cells exhibit a de-repression of CD4 expression unlike in wild-type mice (J:158962)
abnormal CD8-positive, alpha-beta T cell number ( J:125953 )
• reduced number of single positive CD8 T cells
increased IgA level ( J:125953 )
• at least 10 fold higher levels in the serum
increased IgE level ( J:125953 )
• at least 10 fold higher levels in the serum
increased IgG1 level ( J:125953 )
• at least 10 fold higher levels of IgG1 in the serum
lung inflammation ( J:125953 )
• an asthma-like disease occurs with lymphocytes and eosinophils infiltrating the bronchioles, perivascular space, and the alveolar septae

hematopoietic system
abnormal T cell differentiation ( J:125953 )
• slight reduction in number of mature T cells in the thymus
• Cbfbeta protein is detectable in T cells of the thymus but not the periphery
abnormal T-helper 1 cell differentiation ( J:125953 )
• significant levels of the Th-2 cytokine IL-4 are produced when nave T cells are activated in vitro
• some T cells produce both IL-4 and IFN-gamma when nave T cells are cultured under Th1 polarizing conditions
abnormal CD8-positive, alpha beta T cell morphology ( J:125953 , J:158962 )
• vast majority of CD8-positive T cells in the periphery also express CD4 (J:125953)
• CD8+ T cells exhibit a de-repression of CD4 expression unlike in wild-type mice (J:158962)
abnormal CD8-positive, alpha-beta T cell number ( J:125953 )
• reduced number of single positive CD8 T cells
increased IgA level ( J:125953 )
• at least 10 fold higher levels in the serum
increased IgE level ( J:125953 )
• at least 10 fold higher levels in the serum
increased IgG1 level ( J:125953 )
• at least 10 fold higher levels of IgG1 in the serum

respiratory system
lung inflammation ( J:125953 )
• an asthma-like disease occurs with lymphocytes and eosinophils infiltrating the bronchioles, perivascular space, and the alveolar septae




Genotype
MGI:4452098
cn6
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Rr94tm3.1Litt/Rr94tm3.1Litt
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Rr94tm3.1Litt mutation (0 available); any Rr94 mutation (0 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-positive T cell morphology ( J:158962 )
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice

hematopoietic system
abnormal double-positive T cell morphology ( J:158962 )
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
abnormal T cell subpopulation ratio ( J:158962 )
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:158962 )
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
11/19/2024
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