Analysis Tools|
Allele Symbol Allele Name Allele ID |
Il36rntm1Hblu targeted mutation 1, Hal Blumberg MGI:3762028 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice develop more severe imiquimod-induced skin inflammation and psoriasis than wild-type mice
|
|
• mice develop more severe imiquimod-induced skin inflammation and psoriasis than wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice display no overt phenotype including normal histopathology and immune system
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• only 1 mouse was found at weaning and 13 dead mice were recovered prior to weaning with milk in their stomachs but small and dehydrated
• however, treatment with 50 ug M616 at P1, 3 and 5 rescues lethality
|
|
• mice exhibit a dilation of superficial dermal blood vessels
|
|
• mice that die during the postnatal period have a dehydrated appearance
• however, skin barrier function at E18.5 and P3 is normal
|
|
• mice are smaller than wild-type mice
|
|
• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
|
|
• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
• while treatment with 50 ug M616 at P1, 3 and 5 rescues lethality mice develop severe lesions on their face, neck and ears by 4 to 6 weeks when the treatment is withdrawn
|
|
• mice exhibit intracorneal and intraepithelial pustules, nucleated corneocytes, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
|
|
• mice exhibit orthokeratotic hyperkeratinosis
|
|
• mice exhibit parakerototic hyperkeratinosis
|
|
• at P3 mice develop an abnormal skin phenotype resembling blistering
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit a dilation of superficial dermal blood vessels
|
|
• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
|
|
• mice exhibit a mixed dermal inflammatory infiltrate containing predominantly neutrophils and macrophages with fewer lymphocytes and rare eosinophils
|
|
• mice exhibit intracorneal and intraepithelial pustules, parakerototic and orthokeratotic hyperkeratinosis, dilated superficial dermal blood vessels, and a mixed dermal inflammatory infiltrate
|
|
• mice exhibit orthokeratotic hyperkeratinosis
|
|
• mice exhibit parakeratotic hyperkeratinosis
|
|
• mice have regions of thick and scaly skin
|
|
• mice have regions of thick and scaly skin
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/19/2024 MGI 6.24 |
|
|
|
||
