Phenotypes associated with this allele

• Allele Symbol: Tg(CD207-Dta)312Dhka
• Allele Name: transgene insertion 312, Daniel H Kaplan
• Allele ID: MGI:3762048
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Flg^tm1Amag/Flg^tm1Amag Tg(CD207-Dta)312Dhka/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6NTac * FVB	MGI:6246531
tg2	Tg(CD207-Dta)312Dhka/?	FVB-Tg(CD207-Dta)312Dhka	MGI:3762118

Genotype
MGI:6246531

cx1

• Allelic Composition: Flg^tm1Amag/Flg^tm1Amag; Tg(CD207-Dta)312Dhka/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6NTac * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased inflammatory response ( J:229771 )

• Th17 and gammadeltaT17 responses induced by topical S. aureus inoculation are abrogated, indicating that Langerhans cells mediate IL-17 responses against S. aureus

Genotype
MGI:3762118

tg2

• Allelic Composition: Tg(CD207-Dta)312Dhka/?
• Genetic Background: FVB-Tg(CD207-Dta)312Dhka

immune system

absent Langerhans cell ( J:113309 )

• unlike in wild-type mice, Langerhans cells in the epidermis are absent

• however, Langerhans cells are present in secondary lymph nodes and the thymus

increased susceptibility to type IV hypersensitivity reaction ( J:113309 )

• after priming with hapten applied to shaved skin and rechallenge with hapten, mice exhibit a 2-fold increase in ear swelling compared to similarly treated wild-type mice that persists even 3 days after treatment with haptens 2,4-dinitro-1-fluorobenzene or oxazalone

• however, inflammatory response to sodium dodecyl sulfate or benzalkonium chloride is normal as is ovalbumin-induced T cell proliferation

hematopoietic system

absent Langerhans cell ( J:113309 )

• unlike in wild-type mice, Langerhans cells in the epidermis are absent

• however, Langerhans cells are present in secondary lymph nodes and the thymus