Phenotypes associated with this allele

• Allele Symbol: Gad1^tm1.1Rpa
• Allele Name: targeted mutation 1.1, Richard D Palmiter
• Allele ID: MGI:3762150
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gad1^tm1.1Rpa/Gad1^tm1.1Rpa	Not Specified	MGI:3762152
ht2	Gad1^tm1.1Rpa/Gad1^+	Not Specified	MGI:3762155
cn3	Drd1^tm1(cre)Rpa/Drd1^+ Gad1^tm1Rpa/Gad1^tm1.1Rpa	involves: 129S4/SvJaeSor * C57BL/6	MGI:3806595

Genotype
MGI:3762152

hm1

• Allelic Composition: Gad1^tm1.1Rpa/Gad1^tm1.1Rpa
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:126581 , J:138586 )

• mice do not survive beyond the perinatal period (J:126581)

Genotype
MGI:3762155

ht2

• Allelic Composition: Gad1^tm1.1Rpa/Gad1⁺
• Genetic Background: Not Specified

nervous system

abnormal brain interneuron morphology ( J:126581 )

• basket interneurons display reduction in the number of terminal branches, and the density and size of boutons around pyramidal cell somata (4.2+/-0.2 boutons per soma compared to 9.8+/-0.3 boutons per soma in wild-type mice)basket interneurons display reduction in the number of terminal branches, and the density and size of boutons around pyramidal cell somata (4.2+/-0.2 boutons per soma compared to 9.8+/-0.3 boutons per soma in wild-type mice)

Genotype
MGI:3806595

cn3

• Allelic Composition: Drd1^tm1(cre)Rpa/Drd1⁺; Gad1^tm1Rpa/Gad1^tm1.1Rpa
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:138586 )

N • mice exhibit normal gait and response to the Drd1a agonist SKF81297

limb grasping ( J:138586 )

abnormal motor coordination/balance ( J:138586 )

• mice spend more time on a rotarod than heterozygous controls

decreased grip strength ( J:138586 )

• on the second of three trials mice exhibit decreased strength in a modified wire hang test compared to heterozygous controls