mortality/aging
• mice do not survive beyond the perinatal period
(J:126581)
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Allele Symbol Allele Name Allele ID |
Gad1tm1.1Rpa targeted mutation 1.1, Richard D Palmiter MGI:3762150 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice do not survive beyond the perinatal period
(J:126581)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• basket interneurons display reduction in the number of terminal branches, and the density and size of boutons around pyramidal cell somata (4.2+/-0.2 boutons per soma compared to 9.8+/-0.3 boutons per soma in wild-type mice)basket interneurons display reduction in the number of terminal branches, and the density and size of boutons around pyramidal cell somata (4.2+/-0.2 boutons per soma compared to 9.8+/-0.3 boutons per soma in wild-type mice)
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal gait and response to the Drd1a agonist SKF81297
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• mice spend more time on a rotarod than heterozygous controls
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• on the second of three trials mice exhibit decreased strength in a modified wire hang test compared to heterozygous controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/17/2024 MGI 6.24 |
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