Phenotypes associated with this allele

• Allele Symbol: Psmd4^tm1Smta
• Allele Name: targeted mutation 1, Shigep Murata
• Allele ID: MGI:3762160
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmd4^tm1Smta/Psmd4^tm1Smta	involves: C57BL/6 * CBA	MGI:3762182

Genotype
MGI:3762182

hm1

• Allelic Composition: Psmd4^tm1Smta/Psmd4^tm1Smta
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:126546 )

• mice are resorbed by E7.5

embryo

absent inner cell mass proliferation ( J:126546 )

• after 48 hours in culture, inner cell mass cells cease to expand and detach from trophoblastic cells before 96 hours unlike wild-type cells

abnormal gastrulation ( J:126546 )

• at E6.5, mice fail to form a two-layered cylinder-like cellular structure observed in wild-type mice

cellular

absent inner cell mass proliferation ( J:126546 )

• after 48 hours in culture, inner cell mass cells cease to expand and detach from trophoblastic cells before 96 hours unlike wild-type cells