Analysis Tools
homeostasis/metabolism
|
• leptin levels are decreased (on a normal diet, 3.5+/-0.21 ng/ml compared to 0.6+/-0.14 ng/ml in wild-type mice; on a high fat diet, 7.76+/-0.88 ng/ml compared to 2.80+/-0.54 ng/ml in wild-type mice)
|
|
• under a normal diet 0.6.+/-0.09 mEq/l compared to 1.02+/-0.15 mEq/l in wild-type mice
|
|
• 0.48+/-0.06 mmol/l compared to 0.82+/-0.15 mmol/l in wild-type mice when fed a high fat diet
|
|
• 8.53+/-0.54 ug/ml compared to 6.62+/-0.61 ng/ml for wild-type mice when fed a high fat diet
|
adipose tissue
|
• on a normal diet adiposity is reduced by 52% (4.44% compared with 9.22% in wild-type mice) and on a high fat diet adiposity is reduced by 46% (10.10% compared with 19.01% in wild-type mice)
|
|
• whether on a normal or high fat diet, fat pads are reduced compared to in wild-type mice
|
|
• white adipose tissue is more compact than in wild-type mice
|
behavior/neurological
|
• 5.00+/-0.066 g/day compared to 4.41+/-0.046 g/day in wild-type mice
|
growth/size/body
|
• after 19 weeks on a high fat diet, mice weight less than wild-type mice (37.05+/-1.32 g compared to 43.83+/-1.19 g)
|
liver/biliary system
| N |
• mice are resistant to diet-induced steatosis
|
immune system
|
• spleen weight is decreased compared to wild-type when fed a normal diet (0.07+/-0.003 g compared to 0.10+/-0.003 g)
|
hematopoietic system
|
• spleen weight is decreased compared to wild-type when fed a normal diet (0.07+/-0.003 g compared to 0.10+/-0.003 g)
|
