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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(2Hoxd4-Hoxd13)30Ddu
deletion, Chr 2, Denis Duboule 30
MGI:3762256
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Del(2Hoxd4-Hoxd13)30Ddu/Del(2Hoxd4-Hoxd13)30Ddu involves: 129S2/SvPas MGI:3762328
ht2
Del(2Hoxd4-Hoxd13)30Ddu/+ involves: 129S2/SvPas MGI:3810775


Genotype
MGI:3762328
hm1
Allelic
Composition
Del(2Hoxd4-Hoxd13)30Ddu/Del(2Hoxd4-Hoxd13)30Ddu
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most of the severely growth retarded animals die within 2 weeks of birth (J:92363)
• 40% to 50% of mice die shortly after birth (J:131874)

renal/urinary system
N
• mice have normal kidney size at birth
• mice exhibit increased apoptosis in the kidney, specifically in the cortical interstitium and microcystic tubules, compared to in wild-type mice
• increased apoptosis in the microcystic renal tubules
• tubules exhibit microcystic changes such as thin epithelial cells and the lumina is widened compared to in wild-type mice

digestive/alimentary system
• ileocecal sphincter at junction between large and small bowel is absent, resulting in continuous transition from lower ileum to colon
• at this transition point, smooth muscle layer is thin and disorganized compared to controls
• there are signs of aberrant cell differentiation in pyloric region of stomach with ectopic islands of alkaline phosphatase-positive cells located in epithelium

growth/size/body
• after first week postnatal, pups show growth retardation with ~1/3 reaching less than 50% of normal bodyweight

muscle
• ileocecal sphincter is absent

cellular
• mice exhibit increased apoptosis in the kidney, specifically in the cortical interstitium and microcystic tubules, compared to in wild-type mice
• increased apoptosis in the microcystic renal tubules




Genotype
MGI:3810775
ht2
Allelic
Composition
Del(2Hoxd4-Hoxd13)30Ddu/+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• in some mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory