Phenotypes associated with this allele

• Allele Symbol: Ccl19^tm1Cys
• Allele Name: targeted mutation 1, Jason G Cyster
• Allele ID: MGI:3762257
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl19^tm1Cys/Ccl19^tm1Cys	B6.129X1-Ccl19^tm1Cys	MGI:3762258
hm2	Ccl19^tm1Cys/Ccl19^tm1Cys	involves: 129X1/SvJ	MGI:6149991

Genotype
MGI:3762258

hm1

• Allelic Composition: Ccl19^tm1Cys/Ccl19^tm1Cys
• Genetic Background: B6.129X1-Ccl19^tm1Cys

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:126345 )

• despite lowered T cell numbers, mice exhibit normal short-term migration of naive T lymphocytes

decreased T cell number ( J:126345 )

• mice have fewer CD4+ and CD8+ T cells

• however, mice exhibit normal B cell numbers

• mice exhibit a 30% reduction in T cells that is not thymus-dependent and likely due to a decrease in T cell survival

hematopoietic system

decreased T cell number ( J:126345 )

• mice have fewer CD4+ and CD8+ T cells

• however, mice exhibit normal B cell numbers

• mice exhibit a 30% reduction in T cells that is not thymus-dependent and likely due to a decrease in T cell survival

Genotype
MGI:6149991

hm2

• Allelic Composition: Ccl19^tm1Cys/Ccl19^tm1Cys
• Genetic Background: involves: 129X1/SvJ

immune system

immune system phenotype ( J:244640 )

N • mice exhibit normal sized thymus medulla and no lacrimal and salivary glands inflammation