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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacnb2tm1Mfre
targeted mutation 1, Marc Freichel
MGI:3762346
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cacnb2tm1Mfre/Cacnb2tm1.1Mfre
Myl2tm1(cre)Krc/Myl2+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N MGI:3762360


Genotype
MGI:3762360
cn1
Allelic
Composition		 Cacnb2tm1Mfre/Cacnb2tm1.1Mfre
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1.1Mfre mutation (0 available); any Cacnb2 mutation (50 available)
Cacnb2tm1Mfre mutation (0 available); any Cacnb2 mutation (50 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
decreased heart rate ( J:126506 )
• the beating frequency of E13.5 heart explants is reduced compared to for wild-type hearts
abnormal myocardial fiber physiology ( J:126506 )
• calcium channel current density is reduced compared to in wild-type mice (-12.3+/-0.6 mV compared to -16.9+/-07 mV in wild-type mice)

embryo
abnormal vitelline vascular remodeling ( J:126506 )
• between E11.5 and E12.5, vascular remodeling of the primary capillary plexus fails to occur and a honeycomb-like network of tubules with enlarged and uniform diameters forms in the extra- and intraembryonic vasculature




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory