About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacnb2tm1Mfre
targeted mutation 1, Marc Freichel
MGI:3762346
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cacnb2tm1Mfre/Cacnb2tm1.1Mfre
Myl2tm1(cre)Krc/Myl2+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N MGI:3762360


Genotype
MGI:3762360
cn1
Allelic
Composition		 Cacnb2tm1Mfre/Cacnb2tm1.1Mfre
Myl2tm1(cre)Krc/Myl2+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacnb2tm1.1Mfre mutation (0 available); any Cacnb2 mutation (50 available)
Cacnb2tm1Mfre mutation (0 available); any Cacnb2 mutation (50 available)
Myl2tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
decreased heart rate ( J:126506 )
• the beating frequency of E13.5 heart explants is reduced compared to for wild-type hearts
abnormal myocardial fiber physiology ( J:126506 )
• calcium channel current density is reduced compared to in wild-type mice (-12.3+/-0.6 mV compared to -16.9+/-07 mV in wild-type mice)

embryo
abnormal vitelline vascular remodeling ( J:126506 )
• between E11.5 and E12.5, vascular remodeling of the primary capillary plexus fails to occur and a honeycomb-like network of tubules with enlarged and uniform diameters forms in the extra- and intraembryonic vasculature




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory