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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lime1tm1.1Mal
targeted mutation 1.1, Bernard Malissen
MGI:3762394
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lime1tm1.1Mal/Lime1tm1.1Mal involves: 129S2/SvPas * C57BL/6 MGI:3762493
cx2
 		Lime1tm1.1Mal/Lime1tm1.1Mal
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/? 		B6.Cg-Rag2tm1Fwa Lime1tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas MGI:3762494
cx3
 		Lat2tm1Mal/Lat2tm1Mal
Lime1tm1.1Mal/Lime1tm1.1Mal 		involves: 129 * C57BL/6 MGI:3762495
cx4
 		Lime1tm1.1Mal/Lime1tm1.1Mal
Pag1tm1Sbln/Pag1tm1Sbln 		involves: 129S2/SvPas MGI:5301870


Genotype
MGI:3762493
hm1
Allelic
Composition		 Lime1tm1.1Mal/Lime1tm1.1Mal
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:126321 )
N
• No abnormal phenotype observed in the development, number, or physiology of B cells, T cells, and natural killer cells




Genotype
MGI:3762494
cx2
Allelic
Composition		 Lime1tm1.1Mal/Lime1tm1.1Mal
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic
Background		 B6.Cg-Rag2tm1Fwa Lime1tm1.1Mal Tg(TcraH-Y,TcrbH-Y)1Pas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(TcraH-Y,TcrbH-Y)1Pas mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive T cell differentiation ( J:126321 )
• 1.8 fold increase in clonotype positive cells in the thymus of female but not male mice
increased CD4-positive, alpha-beta T cell number ( J:126321 )
• 3 fold increase in clonotype CD4 T cells in female but not male mice

immune system
abnormal CD4-positive T cell differentiation ( J:126321 )
• 1.8 fold increase in clonotype positive cells in the thymus of female but not male mice
increased CD4-positive, alpha-beta T cell number ( J:126321 )
• 3 fold increase in clonotype CD4 T cells in female but not male mice




Genotype
MGI:3762495
cx3
Allelic
Composition		 Lat2tm1Mal/Lat2tm1Mal
Lime1tm1.1Mal/Lime1tm1.1Mal
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Mal mutation (1 available); any Lat2 mutation (19 available)
Lime1tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased anti-nuclear antigen antibody level ( J:126321 )
• detectable in 5 of 7 individuals




Genotype
MGI:5301870
cx4
Allelic
Composition		 Lime1tm1.1Mal/Lime1tm1.1Mal
Pag1tm1Sbln/Pag1tm1Sbln
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lime1tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
Pag1tm1Sbln mutation (0 available); any Pag1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:177766 )
• mice are viable and fertile




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory