Phenotypes associated with this allele

• Allele Symbol: Dusp1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3762529
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp1^tm1Lex/Dusp1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3762537

Genotype
MGI:3762537

hm1

• Allelic Composition: Dusp1^tm1Lex/Dusp1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased circulating interferon-gamma level ( J:126383 )

• two hours after low dose LPS challenge, mice have 3 fold higher levels of IFN-gamma in serum

increased circulating tumor necrosis factor level ( J:126383 )

• two hours after low dose LPS challenge, mice have 5 fold higher levels of circulating TNF

• significantly increased serum levels found in mice with collagen induced arthritis

• enhanced production of TNF by bone marrow derived macrophages when cultured with any of the ligands for toll-like receptors (TLR) 2-5 and TLR9

abnormal chemokine level ( J:126383 )

• two hours after low dose LPS challenge, mice have increased levels of MCP-1

abnormal interleukin level ( J:126383 )

• two hours after low dose LPS challenge, mice have increased levels of IL-12p70

increased circulating interleukin-10 level ( J:126383 )

• two hours after low dose LPS challenge, mice have 5 fold higher levels in serum

increased circulating interleukin-6 level ( J:126383 )

• two hours after low dose LPS challenge, mice have 2.5 fold higher levels of IL-6 in serum

• significantly increased serum levels found in mice with collagen induced arthritis

increased susceptibility to induced arthritis ( J:126383 )

• Upon collagen immunization, a much more severe form of arthritis develops with onset occurring a week earlier and persisting at least a week longer than in wild-type littermates

increased susceptibility to endotoxin shock ( J:126383 )

• all mice die within 48 hours of low dose LPS challenge while all wild-type littermates survive

abnormal innate immunity ( J:126383 )

• enhanced production of TNF by bone marrow derived macrophages when cultured with any of the ligands for toll-like receptors (TLR) 2-5 and TLR9

skeleton

increased susceptibility to induced arthritis ( J:126383 )

• Upon collagen immunization, a much more severe form of arthritis develops with onset occurring a week earlier and persisting at least a week longer than in wild-type littermates

homeostasis/metabolism

increased circulating interferon-gamma level ( J:126383 )

• two hours after low dose LPS challenge, mice have 3 fold higher levels of IFN-gamma in serum

increased circulating tumor necrosis factor level ( J:126383 )

• two hours after low dose LPS challenge, mice have 5 fold higher levels of circulating TNF

• significantly increased serum levels found in mice with collagen induced arthritis

• enhanced production of TNF by bone marrow derived macrophages when cultured with any of the ligands for toll-like receptors (TLR) 2-5 and TLR9

increased prostaglandin level ( J:126383 )

• two hours after low dose LPS challenge, levels in serum are slightly elevated

abnormal chemokine level ( J:126383 )

• two hours after low dose LPS challenge, mice have increased levels of MCP-1

abnormal interleukin level ( J:126383 )

• two hours after low dose LPS challenge, mice have increased levels of IL-12p70

increased circulating interleukin-10 level ( J:126383 )

• two hours after low dose LPS challenge, mice have 5 fold higher levels in serum

increased circulating interleukin-6 level ( J:126383 )

• two hours after low dose LPS challenge, mice have 2.5 fold higher levels of IL-6 in serum

• significantly increased serum levels found in mice with collagen induced arthritis