Phenotypes associated with this allele

• Allele Symbol: Trp53^tm4Xu
• Allele Name: targeted mutation 4, Yang Xu
• Allele ID: MGI:3762530
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm4Xu/Trp53^tm4Xu	Not Specified	MGI:3762544
ht2	Trp53^tm4Xu/Trp53^+	Not Specified	MGI:3762545

Genotype
MGI:3762544

hm1

• Allelic Composition: Trp53^tm4Xu/Trp53^tm4Xu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:126497 )

• mice succumb to tumorigenesis by 8 months of age

neoplasm

abnormal tumor incidence ( J:126497 )

• mice succumb to tumorigenesis by 8 months of age

increased tumor incidence ( J:126497 )

• 2 of 30 mice develop germ-cell tumors compared to 0 of 26 p53-null mice

increased lymphoma incidence ( J:126497 )

• 7 of 30 mice develop peripheral lymphomas compared to 0 of 26 p53-null mice

increased T cell derived lymphoma incidence ( J:126497 )

• 12 of 30 mice develop thymomas compared to 18 of 26 p53-null mice

increased sarcoma incidence ( J:126497 )

• 10 of 30 mice develop sarcomas, including hemangiosarcomas (4 of the 10) and rhabosarcomas (4 if the 10), compared to 8 of 26 p53-null mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126497 )

• 12 of 30 mice develop thymomas compared to 18 of 26 p53-null mice

cellular

abnormal cell cycle checkpoint function ( J:126497 )

• the G2 to M check point is impaired after irradiation of mouse embryonic fibroblasts

decreased apoptosis ( J:126497 )

• p53-dependent apoptosis following exposure to radiation is abolished

spontaneous chromosome breakage ( J:126497 )

• unlike in p53-null mice or Trp53^tm1Holl homozygotes, 78% of pre-tumor thymi contained chromosomal translocations

hematopoietic system

increased T cell derived lymphoma incidence ( J:126497 )

• 12 of 30 mice develop thymomas compared to 18 of 26 p53-null mice

immune system

increased T cell derived lymphoma incidence ( J:126497 )

• 12 of 30 mice develop thymomas compared to 18 of 26 p53-null mice

Genotype
MGI:3762545

ht2

• Allelic Composition: Trp53^tm4Xu/Trp53⁺
• Genetic Background: Not Specified

neoplasm

neoplasm ( J:126497 )

N • no tumors are detected in mice up to 1 year of age

cellular

cellular phenotype ( J:160414 )

N • mouse embryonic fibroblasts exhibit a normal G2/M checkpoint after irradiation