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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm5Xu
targeted mutation 5, Yang Xu
MGI:3762531
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm5Xu/Trp53tm5Xu Not Specified MGI:3767798


Genotype
MGI:3767798
hm1
Allelic
Composition		 Trp53tm5Xu/Trp53tm5Xu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm5Xu mutation (0 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased apoptosis ( J:126497 )
• p53-dependent cell-cycle arrest and apoptosis were abolished
spontaneous chromosome breakage ( J:126497 )
• interchromosomal translocations were detected in 35% of pre-tumor thymus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory