Analysis Tools
endocrine/exocrine glands
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• induction of Tcf3 beginning on P1 impairs the end stage of sebaceous gland differentiation
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• 48 hours after doxycycline treatment, numbers of sebocytes are reduced
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• by 4 days of doxycycline administration, sebocytes are no longer detected
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digestive/alimentary system
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• when pregnant double transgenic mice are administered doxycycline when the embryos are E13.5, epidermal differentiation in the tongue of pups is significantly impaired when examined at P1; the differentiation marker loricrin is reduced in the epithelium, while the simple epithelial marker K8 shows significant induction of expression
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craniofacial
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• when pregnant double transgenic mice are administered doxycycline when the embryos are E13.5, epidermal differentiation in the tongue of pups is significantly impaired when examined at P1; the differentiation marker loricrin is reduced in the epithelium, while the simple epithelial marker K8 shows significant induction of expression
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integument
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• induction of Tcf3 beginning on P1 impairs the end stage of sebaceous gland differentiation
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• 48 hours after doxycycline treatment, numbers of sebocytes are reduced
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• by 4 days of doxycycline administration, sebocytes are no longer detected
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• after induction of Tcf3 with doxycycline treatment beginning on P1, hair follicle maturation is impaired; follicle downgrowth appears to arrest with Tcf3 induction
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• when skin from doxycycline-treated P transgenic is transplanted onto control mice, by day 27 specified follicles have undergone degeneration and fail to reenter the hair cycle
• epidermis and residual established hair follicles in grafts have developed into large masses of undifferentiated epithelial cells lacking all markers of epidermal terminal differentiation
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• keratohyalin granules, loricrin, and involucrin are dramatically reduced within 4 days of doxycycline administration starting on P1
• flattened squames are present at the skin surface; these appear to be dead keratinocytes
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• within 4 days of doxycycline administration starting on P1, thick filament bundles characteristic of spinous layer K1/K10 filaments are barely detectable
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• epidermal differentiation is severely diminished within 4 days of doxycycline administration (resulting in Tcf3 induction) starting at postnatal day 1
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growth/size/body
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• when pregnant double transgenic mice are administered doxycycline when the embryos are E13.5, epidermal differentiation in the tongue of pups is significantly impaired when examined at P1; the differentiation marker loricrin is reduced in the epithelium, while the simple epithelial marker K8 shows significant induction of expression
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