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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zpbp2tm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:3762590
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zpbp2tm1Zuk/Zpbp2tm1Zuk involves: 129S7/SvEvBrd * C57BL/6J MGI:3762592
cx2
 		Zpbptm1Zuk/Zpbptm1Zuk
Zpbp2tm1Zuk/Zpbp2tm1Zuk 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3762594
cx3
 		Zpbptm1Zuk/Zpbp+
Zpbp2tm1Zuk/Zpbp2tm1Zuk 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3762595
cx4
 		Zpbptm1Zuk/Zpbp+
Zpbp2tm1Zuk/Zpbp2+ 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3762596


Genotype
MGI:3762592
hm1
Allelic
Composition		 Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpbp2tm1Zuk mutation (1 available); any Zpbp2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:126661 )
N
• total testis weight is similar to wild-type and heterozygous littermates
teratozoospermia ( J:126661 )
• subtle deformities are seen including; a shortened apical hook, smaller apical angle, and bulges composed of excessive acrosome folded onto itself
• however, sperm counts and motility are similar to heterozygous males
reduced male fertility ( J:126661 )
• decreased litter size in crosses to heterozygous females relative to crosses of homozygous females to heterozygous males and heterozygous crosses
• however, female fertility is normal
delayed fertilization ( J:126661 )
• in vitro fertilization rates with zona-intact eggs are slower relative to rates for heterozygous males

cellular
teratozoospermia ( J:126661 )
• subtle deformities are seen including; a shortened apical hook, smaller apical angle, and bulges composed of excessive acrosome folded onto itself
• however, sperm counts and motility are similar to heterozygous males




Genotype
MGI:3762594
cx2
Allelic
Composition		 Zpbptm1Zuk/Zpbptm1Zuk
Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpbp2tm1Zuk mutation (1 available); any Zpbp2 mutation (25 available)
Zpbptm1Zuk mutation (1 available); any Zpbp mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:126661 )
• only about 10% of sperm are motile compared to 68% motility in controls
abnormal Sertoli cell morphology ( J:126661 )
• abnormal vesicles made of acrosome fragments coated with junctional structures are present in the cytoplasm
abnormal spermatogenesis ( J:126661 )
• profound fragmentation and degradation of the acrosome in spermatids
teratozoospermia ( J:126661 )
• additional abnormalities including misshapen nuclei, detached flagella, and disorganized mitochondria within excessive cytoplasmic droplets are seen
abnormal sperm flagellum morphology ( J:126661 )
• disorganized mitochondria within excessive cytoplasmic droplets are seen
coiled sperm flagellum ( J:126661 )
• the proportion of sperm with coiled flagella increases from the proximal caput epididymis to the caudal epididymis
abnormal acrosome morphology ( J:126661 )
• only abnormally shaped acrosome fragments are seen in ~20% of sperm
globozoospermia ( J:126661 )
• most caudal epididymal sperm have a round-head with the tail coiled around the nucleus
absent acrosome ( J:126661 )
• the acrosome is absent in over 80% of sperm
abnormal sperm nucleus morphology ( J:126661 )
• misshapen nuclei are observed
abnormal spermatid morphology ( J:126661 )
• dilated acrosome, detached of eccentric acrosomal granules, and occasional nuclear indentation by the dilated acrosome are seen as early as in step 6 to 8 spermatids
male infertility ( J:126661 )
• associated with severe deformation of the spermatozoa
• despite normal sperm counts

endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:126661 )
• abnormal vesicles made of acrosome fragments coated with junctional structures are present in the cytoplasm

cellular
teratozoospermia ( J:126661 )
• additional abnormalities including misshapen nuclei, detached flagella, and disorganized mitochondria within excessive cytoplasmic droplets are seen
abnormal sperm flagellum morphology ( J:126661 )
• disorganized mitochondria within excessive cytoplasmic droplets are seen
coiled sperm flagellum ( J:126661 )
• the proportion of sperm with coiled flagella increases from the proximal caput epididymis to the caudal epididymis
abnormal acrosome morphology ( J:126661 )
• only abnormally shaped acrosome fragments are seen in ~20% of sperm
globozoospermia ( J:126661 )
• most caudal epididymal sperm have a round-head with the tail coiled around the nucleus
absent acrosome ( J:126661 )
• the acrosome is absent in over 80% of sperm
abnormal sperm nucleus morphology ( J:126661 )
• misshapen nuclei are observed
abnormal spermatid morphology ( J:126661 )
• dilated acrosome, detached of eccentric acrosomal granules, and occasional nuclear indentation by the dilated acrosome are seen as early as in step 6 to 8 spermatids
asthenozoospermia ( J:126661 )
• only about 10% of sperm are motile compared to 68% motility in controls




Genotype
MGI:3762595
cx3
Allelic
Composition		 Zpbptm1Zuk/Zpbp+
Zpbp2tm1Zuk/Zpbp2tm1Zuk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpbp2tm1Zuk mutation (1 available); any Zpbp2 mutation (25 available)
Zpbptm1Zuk mutation (1 available); any Zpbp mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:126661 )
• increase in the percentage of abnormal sperm
reduced male fertility ( J:126661 )
• average litter size and number of litters over 6 months are significantly reduced compared to wild-type males
• reduction is greater than that seen in double heterozygous males

cellular
teratozoospermia ( J:126661 )
• increase in the percentage of abnormal sperm




Genotype
MGI:3762596
cx4
Allelic
Composition		 Zpbptm1Zuk/Zpbp+
Zpbp2tm1Zuk/Zpbp2+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zpbp2tm1Zuk mutation (1 available); any Zpbp2 mutation (25 available)
Zpbptm1Zuk mutation (1 available); any Zpbp mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:126661 )
• increase in the percentage of abnormal sperm
reduced male fertility ( J:126661 )
• average litter size and number of litters over 6 months are slightly but significantly reduced compared to wild-type males

cellular
teratozoospermia ( J:126661 )
• increase in the percentage of abnormal sperm




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory