Analysis Tools
integument
rough coat
(
J:127018
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• by 2 weeks of age mice exhibit rough coats that is not localized to any anatomical structure and persists throughout life
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• sulfur levels within focal swellings is decreased (1.24+/-0.40% compared to 1.98+/-0.40% in wild-type shafts)
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• in some regions the cuticle splits and eventually breaks exposing the rounded ghost cells
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• heavily pigmented and mildly to non-pigmented hair shafts have defects ranging from loose irregular aggregation of pigment, clumping of pigment within the medulla, clumping with focal distention of the shaft, segregation of pigment with a light brown colored medullary abnormality, to breaking of the hair in the middle of these deformities
• hair shafts display blebs comprising 7.88+/-2.27% of counted hair shafts
• focal distentions are associated with clusters of looses aggregates of round cells associated with fracturing of the cuticle, leading to breakage of the shaft
• all four pelage hair types including vibrissae are affected by hair defects
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• nails on hindfeet, most frequently, in males thicken distally and are often lost
• nail plates are opaque with a rough surface and are overgrown laterally and vertically
• some nail beds are separated from the overlying connective tissue and contain large hemorrhagic areas
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• while some hair follicles appear normal others have focal swellings in the precortical region of the anagen VI-stage follicles immediately above the dermal papilla that contain eosinophilic cells with basophilic nuclei
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• vibrissae contain irregularly spaced bulges with clumping pigment
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