Phenotypes associated with this allele

• Allele Symbol: Gatad2a^tm1Rnu
• Allele Name: targeted mutation 1, Roel Nusse
• Allele ID: MGI:3762633
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gatad2a^tm1Rnu/Gatad2a^tm1Rnu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3762653

Genotype
MGI:3762653

hm1

• Allelic Composition: Gatad2a^tm1Rnu/Gatad2a^tm1Rnu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gatad2a^tm1Rnu/Gatad2a^tm1Rnu mutant embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:126871 )

• homozygous embryos display lethality around E9.5

embryo

abnormal vitelline vasculature morphology ( J:126871 )

• some embryos isolated at E9.5 display missing or excessively large blood vessels in the yolk sac

abnormal embryo turning ( J:126871 )

• some embryos isolated at E9.5 have turned but are underdeveloped, while other embryos have failed to turn despite have 20 or more somites

embryonic growth arrest ( J:126871 )

• majority of homozygous embryos examined isolated at E7.5-10.5 show developmental arrest, and E10.5 show advanced stages of necrosis

• 7/27 isolated at E8.5 display morphology similar to E6-6.5 normal embryos (arrest at egg cylinder stage)

• in homozygous embryos, development of all organs is affected

decreased embryo size ( J:126871 )

• most homozygous embryos isolated between E7.5 and E10.5 are significantly smaller than normal littermates

abnormal neural fold morphology ( J:126871 )

• some homozygous embryos isolated at E9.5 have malformed neural folds that are ruffled and not fused

incomplete rostral neuropore closure ( J:126871 )

• in some embryos isolated at E9.5, anterior neuropore has failed to close

growth/size/body

decreased embryo size ( J:126871 )

• most homozygous embryos isolated between E7.5 and E10.5 are significantly smaller than normal littermates

nervous system

incomplete rostral neuropore closure ( J:126871 )

• in some embryos isolated at E9.5, anterior neuropore has failed to close

cardiovascular system

abnormal vitelline vasculature morphology ( J:126871 )

• some embryos isolated at E9.5 display missing or excessively large blood vessels in the yolk sac