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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Git2Gt(XG510)Byg
gene trap XG510, BayGenomics
MGI:3762635
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Git2Gt(XG510)Byg/Git2Gt(XG510)Byg B6.129P2-Git2Gt(XG510)Byg MGI:4461268
hm2
 		Git2Gt(XG510)Byg/Git2Gt(XG510)Byg C.129P2-Git2Gt(XG510)Byg MGI:4461269
ht3
 		Git2Gt(XG510)Byg/Git2+ involves: 129P2/OlaHsd * C57BL/6 MGI:3762638
cx4
 		Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraH-Y,TcrbH-Y)71Vbo/0 		involves: 129 * C57BL/6J * DBA/2J MGI:4461273
cx5
 		Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(DO11.10)10Dlo/0 		involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6 MGI:4461272
cx6
 		Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraTcrb)425Cbn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:4461270


Genotype
MGI:4461268
hm1
Allelic
Composition		 Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Genetic
Background		 B6.129P2-Git2Gt(XG510)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system

behavior/neurological
increased thermal nociceptive threshold ( J:200082 )
• delayed response in the hot plate test in female mice




Genotype
MGI:4461269
hm2
Allelic
Composition		 Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Genetic
Background		 C.129P2-Git2Gt(XG510)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:3762638
ht3
Allelic
Composition		 Git2Gt(XG510)Byg/Git2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:126878 )
• mice are normal with no differences in body size, organ size, overt behavior, or fertility when compared to wild-type mice




Genotype
MGI:4461273
cx4
Allelic
Composition		 Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background		 involves: 129 * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:160613 )
• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired
decreased CD8-positive, alpha-beta T cell number ( J:160613 )
• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired

immune system
abnormal positive T cell selection ( J:160613 )
• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired
decreased CD8-positive, alpha-beta T cell number ( J:160613 )
• the generation of CD8+ single-positive thymocytes in female H-Y TCR transgenic is impaired

cellular
abnormal cell migration ( J:160613 )
• in the absence of any stimulus basal migration is modestly but consistently greater for the CD4SP and CD8SP subsets of thymocytes




Genotype
MGI:4461272
cx5
Allelic
Composition		 Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(DO11.10)10Dlo/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
Tg(DO11.10)10Dlo mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:160613 )
• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood

immune system
decreased CD4-positive, alpha-beta T cell number ( J:160613 )
• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood




Genotype
MGI:4461270
cx6
Allelic
Composition		 Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Git2Gt(XG510)Byg mutation (3 available); any Git2 mutation (78 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:160613 )
• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood

immune system
decreased CD4-positive, alpha-beta T cell number ( J:160613 )
• single positive cell number in thymus
• transgene positive CD4 cells in spleen, lymph node and blood




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory