Analysis Tools|
Allele Symbol Allele Name Allele ID |
Emx1tm1.1(cre)Ito targeted mutation 1.1, Shigeyoshi Itohara MGI:3762664 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show severe contextual fear learning deficits relative to control littermates, as revealed by a marked reduction in elicited freezing behavior
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• in the hidden version of the Morris water maze, mice search equally in all four quadrants with no clear preference for the target quadrant during the probe trial, and show a significant reduction in their latency time to reach the hidden platform at day 3, but not at the initial or final (day 5) training days relative to control littermates
• however, no significant differences in thigmotaxis, swim speed, or path length are observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• baseline excitatory postsynaptic currents from hippocampal slices are higher than in wild-type
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• the frequency of events is significantly higher in miniature excitatory postsynaptic currents (minis) from CA1 pyramidal neurons
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• (S)-3,5-dihydroxyphenylglycine hydrate (DHPG), an mGluR agonist, fails to produce long-term depression in hippocampal slices
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• decrease in degree of facilitation of the second response in a paired-pulse
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Clcn7tm2Tjj homozygotes, mice have a normal lifespan
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• at 20 weeks in the cerebral cortex
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• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
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• at 20 weeks, the dentate gyrus exhibits conspicuous degeneration unlike in wild-type mice
• hippocampal structures are no longer detected by 1.5 years of age
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• mice exhibit severe neuronal cell loss as early as 30 days after birth
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• the cerebral cortex is reduced at 4 to 5 months of age
• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
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• nearly all cortical neurons are lost by 1 year of age
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• at 20 weeks in the cerebral cortex
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• at 1.5 years of age, the cortex and hippocampus are almost completely degenerated unlike in wild-type mice
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• progressive with severe neuronal cell loss as early as 30 days after birth
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• at 4 to 5 months of age
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• mice exhibit a lysosomal storage phenotype in the forebrain with altered Lamp-1 distribution compared to in wild-type mice
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| N |
• unlike Clcn7tm2Tjj homozygotes, mice exhibit normal bone density
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| N |
• unlike Clcn7tm2Tjj homozygotes, mice exhibit normal growth
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• at 20 weeks in the cerebral cortex
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• at 20 weeks in the cerebral cortex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mortality rate before P35 is around 40%, much lower than Scn1atm2.1Kzy/+ /Tg(Slc32a1-cre)65Kzy littermates (98%; 40/41)
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• mice are normal through week 2 postnatally then develop convulsive seizures in the third week
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• mice are normal through week 2 postnatally then develop convulsive seizures in the third week
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are phsyically normal and do not develop seizures
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• at P21.5, Scn1a immunoreactive neurites oriented toward the pial surface are only occasionally detected relative to control brains, and neurites oriented toward the ventricular surface are not detectable
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• frequency of severe convulsions is higher than in controls but mortality is similar to controls following with 20 mg kainate/kg
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• frequency of severe convulsions is higher than in controls but mortality is similar to controls following with 20 mg kainate/kg
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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