Phenotypes associated with this allele

• Allele Symbol: Shank1^tm1Shng
• Allele Name: targeted mutation 1, Morgan Sheng
• Allele ID: MGI:3762757
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shank1^tm1Shng/Shank1^tm1Shng	involves: 129S4/SvJae * C57BL/6	MGI:3776236

Genotype
MGI:3776236

hm1

• Allelic Composition: Shank1^tm1Shng/Shank1^tm1Shng
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:132277 )

N • brain displays no gross abnormalities in size or morphology

N • synaptic plasticity (LTP) is not altered

abnormal hippocampus pyramidal cell morphology ( J:132277 )

• dendritic spine density of CA1 pyramidal neurons is slightly decreased compared to wild-type

• spine head width is significantly shifted toward smaller spine size

abnormal CNS synapse formation ( J:132277 )

• synapses in CA1 pyramidal region show significant reduction of postsynaptic density (PSD) thickness compared to controls

• loss of largest PSDs relative to wild-type is observed

abnormal CNS synaptic transmission ( J:132277 )

• basal synaptic transmission at the Schaffer collateral/commissural-CA1 synapse in hippocampal slices is reduced; input-output curve is shifted downward at high stimulus intensities

behavior/neurological

abnormal spatial learning ( J:132277 )

• mutants learn faster and more effectively than wild-type during repetitive training in the eight-armed radial maze

abnormal spatial reference memory ( J:132277 )

• in eight-armed radial maze testing paradigm, mutants show enhanced reference memory compared to wild-type; mutants show fewer reference memory errors than wild-type, even with prolonged training

• when tested for 're-learning' using reversal training in the radial maze paradigm, mutants show faster learning and fewer reference memory errors with repeated training

abnormal long-term spatial reference memory ( J:132277 )

• long-term retention of reference memory after end of training is impaired relative to wild-type

• when re-tested after 4 weeks, mutants regress to wild-type performance level, losing the enhancemed learning displayed in the initial testing, while wild-type performance after 28 days is similar to the original level during testing

abnormal spatial working memory ( J:132277 )

• in eight-armed radial maze testing paradigm, mutants show enhanced working memory, making fewer working memory errors than wild-type animals

increased anxiety-related response ( J:132277 )

• mutants display increased anxiety-like behavior in open-field and light/dark exploration tests relative to wild-type

impaired coordination ( J:132277 )

• mild deficit demonstrated by reduced latency to fall in accelerating rotarod test

decreased locomotor activity ( J:132277 )

abnormal maternal nurturing ( J:132277 )

♀ • females do not nurture their offspring; litters generally die before weaning

reproductive system

reduced fertility ( J:132277 )

• mice are poor breeders, rarely giving birth