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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd274tm1.1Lex
targeted mutation 1.1, Lexicon Genetics
MGI:3762770
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd274tm1.1Lex/Cd274tm1.1Lex involves: 129S5/SvEvBrd MGI:3763229


Genotype
MGI:3763229
hm1
Allelic
Composition
Cd274tm1.1Lex/Cd274tm1.1Lex
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm1.1Lex mutation (0 available); any Cd274 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a small reduction in the percentage of CD8+ T cells in lymph nodes and spleens
• no changes were observed for body weight, organ weight, hematology, clinical chemistry, and macroscopic or microscopic findings as compared to wild-type mice
• mice live over 1 year of age, consistent with the lack of obvious pathology

immune system
• a small reduction in the percentage of CD8+ T cells in lymph nodes and spleens
• no changes were observed for body weight, organ weight, hematology, clinical chemistry, and macroscopic or microscopic findings as compared to wild-type mice
• mice live over 1 year of age, consistent with the lack of obvious pathology
• in experimental autoimmune encephalomyelitis model induced by injection of myelin oligodendrocyte glycoprotein, lymph node cells from immunized mutant mice produce higher amounts of pro-inflammatory cytokines
• developed more severe EAE than the wild-type controls in three out of four experiments
• exhibited an increased incidence of EAE in most experiments





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory