Phenotypes associated with this allele

• Allele Symbol: Pdcd1^tm1Llc
• Allele Name: targeted mutation 1, Laura L Carter
• Allele ID: MGI:3762771
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdcd1^tm1Llc/Pdcd1^tm1Llc	involves: 129S5/SvEvBrd	MGI:3763225

Genotype
MGI:3763225

hm1

• Allelic Composition: Pdcd1^tm1Llc/Pdcd1^tm1Llc
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased CD8-positive, alpha-beta T cell number ( J:126829 )

• a small reduction in the percentage of CD8+ T cells in lymph nodes and spleens

• in contrast to the published reports of autoimmune disease in C57BL/6 and BALB/c Pdcd1 -/- mice, no changes were observed for body weight, organ weight, hematology, clinical chemistry, and macroscopic or microscopic findings as compared to wild-type mice

• mice live over 1 year of age, consistent with the lack of obvious pathology

immune system

decreased CD8-positive, alpha-beta T cell number ( J:126829 )

• a small reduction in the percentage of CD8+ T cells in lymph nodes and spleens

• in contrast to the published reports of autoimmune disease in C57BL/6 and BALB/c Pdcd1 -/- mice, no changes were observed for body weight, organ weight, hematology, clinical chemistry, and macroscopic or microscopic findings as compared to wild-type mice

• mice live over 1 year of age, consistent with the lack of obvious pathology

abnormal cytokine secretion ( J:126829 )

• in experimental autoimmune encephalomyelitis model induced by injection of myelin oligodendrocyte glycoprotein, lymph node cells from immunized mutant mice produce higher amounts of pro-inflammatory cytokines

increased susceptibility to experimental autoimmune encephalomyelitis ( J:126829 )

• developed more severe EAE than the wild-type controls

• exhibited an increased incidence of EAE in most experiments