Phenotypes associated with this allele

• Allele Symbol: Prnp^{tm2(PRNP*129M)Tkit}
• Allele Name: targeted mutation 2, Tetsuyuki Kitamoto
• Allele ID: MGI:3762784
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prnp^tm2(PRNP*129M)Tkit/Prnp^tm2(PRNP*129M)Tkit	Not Specified	MGI:3762814
ht2	Prnp^tm2(PRNP*129M)Tkit/Prnp^tm3(PRNP*129V)Tkit	Not Specified	MGI:3762813
cx3	Prnp^tm2(PRNP*129M)Tkit/Prnp^tm2(PRNP*129M)Tkit Tg(Prnp-PRNP*129M)1Tkit/?	Not Specified	MGI:3762870

Genotype
MGI:3762814

hm1

• Allelic Composition: Prnp^{tm2(PRNP*129M)Tkit}/Prnp^{tm2(PRNP*129M)Tkit}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to prion infection ( J:105882 , J:126777 )

• one mouse was are weakly susceptible while others are not susceptible to bovine spongiform encephalopathy prion infection (J:105882)

• mice are less susceptible to infection with non-plaque-type dura matter graft-associated Creutzfeldt-Jakob and sporadic Creutzfeldt-Jakob VV2 than Prnp^{tm3(PRNP*129V)Tkit} homozygotes (J:126777)

increased susceptibility to prion infection ( J:105882 , J:126777 )

• mice are highly susceptible to variant Creutzfeldt-Jakob prion infection (J:105882)

• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prion infection is 467+/-24 days compared to 542 and 648 days for 2 Prnp^{tm3(PRNP*129V)Tkit} homozygous mice (J:126777)

Genotype
MGI:3762813

ht2

• Allelic Composition: Prnp^{tm2(PRNP*129M)Tkit}/Prnp^{tm3(PRNP*129V)Tkit}
• Genetic Background: Not Specified

immune system

decreased susceptibility to prion infection ( J:105882 )

• mice are weakly susceptible to variant Creutzfeldt-Jakob prion infection

Genotype
MGI:3762870

cx3

• Allelic Composition: Prnp^{tm2(PRNP*129M)Tkit}/Prnp^{tm2(PRNP*129M)Tkit}; Tg(Prnp-PRNP*129M)1Tkit/?
• Genetic Background: Not Specified

immune system

decreased susceptibility to prion infection ( J:126777 )

• incubation period following infection with sporadic Creutzfeldt-Jakob VV2 prions is 723+/-79 days compared to 312+/-7 days for Prnp^{tm3(PRNP*129V)Tkit} homozygous mice

increased susceptibility to prion infection ( J:126777 )

• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prions is 429+/-6 days compared to 542 and 648 days for 2 Prnp^{tm3(PRNP*129V)Tkit} homozygous mice

nervous system

abnormal brain morphology ( J:126777 )

• following infection with sporadic Creutzfeldt-Jakob MM1 prion, mice exhibit diffuse synaptic-type prion protein deposits

• following infection with sporadic Creutzfeldt-Jakob VV2 prion, mice exhibit more prominent plaque-type prion protein deposits with larger plaque-type deposits spread throughout the cerebral gray matter and thalamus rather than the white matter