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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prnptm3(PRNP*129V)Tkit
targeted mutation 3, Tetsuyuki Kitamoto
MGI:3762785
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit Not Specified MGI:3762812
ht2
 		Prnptm2(PRNP*129M)Tkit/Prnptm3(PRNP*129V)Tkit Not Specified MGI:3762813
cx3
 		Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Tg(Prnp-PRNP*129V)144Tkit/? 		Not Specified MGI:3762810
cx4
 		Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Tg(Prnp-PRNP*129V)139Tkit/? 		Not Specified MGI:3762811


Genotype
MGI:3762812
hm1
Allelic
Composition		 Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm3(PRNP*129V)Tkit mutation (0 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen morphology ( J:126777 )
• all mice inoculated with brain homogenates from Prnptm2(PRNP*129M)Tkit Tg(Prnp-PRNP*129M)1Tkit mice that succumb to sporadic Creutzfeldt-Jakob VV2 prion infection develop prion protein deposits in the spleen
decreased susceptibility to prion infection ( J:105882 , J:126777 )
• mice are not susceptible to bovine spongiform encephalopathy prion infection (J:105882)
• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prions is 542 and 648 days for 2 mice compared to 467+/-24 days for Prnptm2(PRNP*129M)Tkit homozygotes (J:126777)
• incubation period following infection with sporadic Creutzfeldt-Jakob VV2 prions is 312+/-7 days (J:126777)
increased susceptibility to prion infection ( J:126777 )
• incubation period following infection with plaque-type dura matter graft-associated Creutzfeldt-Jakob (patient KR and KD) prions is 259+/-6 days and 304+/-13 days compared to 420+/-10 days and 398+/-10 days, respectively, in Prnptm5(PRNP*129)Tkit/ Prnptm5(PRNP*129)Tkit Tg(Prnp-PRNP*)1Tkit mice

nervous system
abnormal brain morphology ( J:126777 )
• mice are more susceptible to infection with non-plaque-type dura matter graft-associated Creutzfeldt-Jakob and sporadic Creutzfeldt-Jakob VV2 than Prnptm2(PRNP*129M)Tkit homozygotes
• however, intraperitoneal injection of sporadic Creutzfeldt-Jakob VV2 did not produce prion protein deposits in the spleen

hematopoietic system
abnormal spleen morphology ( J:126777 )
• all mice inoculated with brain homogenates from Prnptm2(PRNP*129M)Tkit Tg(Prnp-PRNP*129M)1Tkit mice that succumb to sporadic Creutzfeldt-Jakob VV2 prion infection develop prion protein deposits in the spleen




Genotype
MGI:3762813
ht2
Allelic
Composition		 Prnptm2(PRNP*129M)Tkit/Prnptm3(PRNP*129V)Tkit
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2(PRNP*129M)Tkit mutation (0 available); any Prnp mutation (142 available)
Prnptm3(PRNP*129V)Tkit mutation (0 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:105882 )
• mice are weakly susceptible to variant Creutzfeldt-Jakob prion infection




Genotype
MGI:3762810
cx3
Allelic
Composition		 Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Tg(Prnp-PRNP*129V)144Tkit/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm3(PRNP*129V)Tkit mutation (0 available); any Prnp mutation (142 available)
Tg(Prnp-PRNP*129V)144Tkit mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:105882 )
• mice are not susceptible to either bovine spongiform encephalopathy or variant Creutzfeldt-Jakob prion infection




Genotype
MGI:3762811
cx4
Allelic
Composition		 Prnptm3(PRNP*129V)Tkit/Prnptm3(PRNP*129V)Tkit
Tg(Prnp-PRNP*129V)139Tkit/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm3(PRNP*129V)Tkit mutation (0 available); any Prnp mutation (142 available)
Tg(Prnp-PRNP*129V)139Tkit mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal susceptibility to infection ( J:126777 )
• incubation period following infection with sporadic Creutzfeldt-Jakob VV2 prions is 183+/-5 days
• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prions is 288+/-9 days
decreased susceptibility to prion infection ( J:105882 )
• mice are not susceptible to either bovine spongiform encephalopathy or variant Creutzfeldt-Jakob prion infection

nervous system
abnormal brain morphology ( J:126777 )
• following infection with sporadic Creutzfeldt-Jakob MM1 prion, mice exhibit diffuse synaptic-type prion protein deposits
• following infection with sporadic Creutzfeldt-Jakob VV2 prion, mice develop small plaque-type prion protein deposits in the white matter and granular to diffuse synaptic-type deposits in the gray matter
• following infection with plaque-type dura matter graft-associated Creutzfeldt-Jakob, mice exhibit small plaque-type prion protein deposits in the cerebral white matter and granular to diffuse synaptic-type deposits in the gray matter similar to those observed in mice infected with sporadic Creutzfeldt-Jakob VV2




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory