Analysis Tools
immune system
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• incubation period following infection with sporadic Creutzfeldt-Jakob VV2 prions is 183+/-5 days
• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prions is 288+/-9 days
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• mice are not susceptible to either bovine spongiform encephalopathy or variant Creutzfeldt-Jakob prion infection
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nervous system
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• following infection with sporadic Creutzfeldt-Jakob MM1 prion, mice exhibit diffuse synaptic-type prion protein deposits
• following infection with sporadic Creutzfeldt-Jakob VV2 prion, mice develop small plaque-type prion protein deposits in the white matter and granular to diffuse synaptic-type deposits in the gray matter
• following infection with plaque-type dura matter graft-associated Creutzfeldt-Jakob, mice exhibit small plaque-type prion protein deposits in the cerebral white matter and granular to diffuse synaptic-type deposits in the gray matter similar to those observed in mice infected with sporadic Creutzfeldt-Jakob VV2
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