Phenotypes associated with this allele

• Allele Symbol: Prnp^{tm5(PRNP*)TKit}
• Allele Name: targeted mutation 5, Tetsuyuki Kitamoto
• Allele ID: MGI:3762867
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prnp^tm5(PRNP*)TKit/Prnp^tm5(PRNP*)TKit	Not Specified	MGI:3762871
cx2	Prnp^tm5(PRNP*)TKit/Prnp^tm5(PRNP*)TKit Tg(Prnp-PRNP*)1Tkit/?	Not Specified	MGI:3762872

Genotype
MGI:3762871

hm1

• Allelic Composition: Prnp^{tm5(PRNP*)TKit}/Prnp^{tm5(PRNP*)TKit}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:126777 )

N • incubation time for mice infected with sporadic Creutzfeldt-Jakob MM1 prions is over 600 days

Genotype
MGI:3762872

cx2

• Allelic Composition: Prnp^{tm5(PRNP*)TKit}/Prnp^{tm5(PRNP*)TKit}; Tg(Prnp-PRNP*)1Tkit/?
• Genetic Background: Not Specified

immune system

decreased susceptibility to prion infection ( J:126777 )

• incubation period following infection with sporadic Creutzfeldt-Jakob VV2 prions is 505+/-14 days

• incubation period following infection with plaque-type dura matter graft-associated Creutzfeldt-Jakob (patient KR, KD and TV) prions is 420+/-10 days, 398+/-10 days, and 584+/-65 days, respectively, compared to 259+/-6 days (infected from patient KR) and 304+/-13 days (infected from patient KD) for Prnp^{tm3(PRNP*129V)Tkit} homozygotes

increased susceptibility to prion infection ( J:126777 )

• incubation period following infection with sporadic Creutzfeldt-Jakob MM1 prions is 175+/-4 days

nervous system

abnormal brain morphology ( J:126777 )

• inoculation with either plaque-type dura matter graft-associated Creutzfeldt-Jakob or sporadic Creutzfeldt-Jakob VV2 prions results in a few plaque-type prion protein deposits

• however, no plaque-type prion protein deposits form in mice infected with non-plaque-type dura matter graft-associated Creutzfeldt-Jakob