Phenotypes associated with this allele

• Allele Symbol: Irak4^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:3762874
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irak4^tm1Aki/Irak4^tm1Aki	involves: 129X1/SvJ * C57BL/6	MGI:3762905

Genotype
MGI:3762905

hm1

• Allelic Composition: Irak4^tm1Aki/Irak4^tm1Aki
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:125729 )

N • T cell activation and responses were normal

decreased B cell proliferation ( J:125729 )

• no proliferation of B cells upon stimulation with TLR ligands except those for TLR3

abnormal cytokine secretion ( J:125729 )

decreased interferon-alpha secretion ( J:125729 )

• no production of IFN-alpha by bone marrow derived dendritic cells upon stimulation with a TLR9 ligand

decreased interleukin-12b secretion ( J:125729 )

• no production of IL12p40 by macrophages upon stimulation with all TLR ligands except those for TLR3

decreased interleukin-6 secretion ( J:125729 )

• no production by macrophages or dendritic cells upon stimulation with various TLR ligands except those for TLR3

decreased tumor necrosis factor secretion ( J:125729 )

• no production by macrophages upon stimulation with TLR ligands except those for TLR3

decreased susceptibility to endotoxin shock ( J:125729 )

• resistant to LPS induced shock

• no lethality when injected with a high dose of LPS

hematopoietic system

decreased B cell proliferation ( J:125729 )

• no proliferation of B cells upon stimulation with TLR ligands except those for TLR3

cellular

decreased B cell proliferation ( J:125729 )

• no proliferation of B cells upon stimulation with TLR ligands except those for TLR3