All Phenotypes Irak4<tm1Lix> MGI Mouse

• 7-fold to 20-fold less found in serum 2 hours after dosing with LPS, CpG, or IL-1

• 5-fold to 100-fold less found in serum 2 hours after dosing with LPS, CpG, or IL-1

abnormal chemokine secretion ( J:125732 )

• reduced production by plasmacytoid DCs in response to ligands for TLR-7 and -9

• reduced production of IFN-alpha by macrophages in response to ligands for TLR-7 and -9

• reduced production of IFN-alpha by dendritic cells in response to influenza virus

• reduced production of IFN-beta by macrophages in response to ligands for TLR-7 and -9

• reduced production of IFN-beta by dendritic cells in response to influenza virus

decreased interleukin-6 secretion ( J:125732 )

• reduced production by macrophages in response to TLR ligands except for a ligand to TLR3

• reduced production of IFN-alpha and IFN-beta by dendritic cells in response to influenza virus

• reduced production by macrophages in response to TLR ligands except for a ligand to TLR3

• reduced production of IFN-alpha and IFN-beta by dendritic cells in response to influenza virus

decreased acute inflammation ( J:125732 )

• resistant to LPS- and CpG- induced shock

• no lethality when injected with a high dose of LPS or CpG

• 7-fold to 20-fold less found in serum 2 hours after dosing with LPS, CpG, or IL-1

• 5-fold to 100-fold less found in serum 2 hours after dosing with LPS, CpG, or IL-1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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