Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ptprvtm1Kry targeted mutation 1, Gerard Karsenty MGI:3762914 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in Ptprvtm1Kry/ Ptprvtm1Kry Tg(Col1a1-cre)1Kry mice, glucose homeostasis is normal
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| N |
• unlike in Ptprvtm1Kry/ Ptprvtm1Kry Tg(Col1a1-cre)1Kry mice, beta-cell proliferation is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal male normal reproductive morphology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• up to 15% of mice die prior to weaning when born to heterozygous mothers and up to 35% die prior to weaning when born to homozygous mothers
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• following an overnight fast, serum levels of free fatty acids are not increased as they are in wild-type mice
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• energy expenditure is higher than in wild-type mice
• however, food intake is not increased
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• insulin-stimulated glucose uptake in muscle, brown and white fat, and liver is increased compared to in wild-type mice
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• blood glucose level at birth prior to milk ingestion is reduced 3-fold or more compared to in wild-type mice
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• adult mice have low blood glucose levels compared to wild-type mice
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• serum adiponectin levels are increased by 2-fold compared to in wild-type mice
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• although fewer adipocytes are present (37+/-5.1x103 adipocytes compared to 93.2+/-10.7x103 adipocytes in wild-type mice), adipocytes are larger than in wild-type mice
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• mice have lighter gonadal fat pads compared to wild-type mice
• decreased fat is restricted to visceral fat
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• white adipose glucose uptake, 31.7+/-8.2 nmol/g/min compared to 16.7+/-2.7 nmol/g/min in wild-type mice; brown adipose tissue, 3330+/-263 nmol/g/min compared to 2022+/-205 nmol/g/min in wild-type mice
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• beta cell proliferation is increased 60% to 300% in 5 day old and 1 month old mice with no increase in apoptosis
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• mice exhibit an increase in pancreas insulin content, the number of islet cells, the size of islet cells and the mass of beta cells
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• beta cell mass is increased
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• mitochondrial area in muscle cells is increased compared to in wild-type cells
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• insulin-stimulated glucose uptake in muscle is increased compared to in wild-type mice
• 358+/-65 nmol/g/min compared to 22+/-29 nmol/g/min in wild-type mice
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• white adipose glucose uptake, 31.7+/-8.2 nmol/g/min compared to 16.7+/-2.7 nmol/g/min in wild-type mice; brown adipose tissue, 3330+/-263 nmol/g/min compared to 2022+/-205 nmol/g/min in wild-type mice
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• mitochondrial area in muscle cells is increased compared to in wild-type cells
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• beta cell proliferation is increased 60% to 300% in 5 day old and 1 month old mice with no increase in apoptosis
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• insulin-stimulated glucose uptake in muscle is increased compared to in wild-type mice
• 358+/-65 nmol/g/min compared to 22+/-29 nmol/g/min in wild-type mice
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| N |
• despite an increase in mitochondrial area muscle mass over body mass ratio is normal
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| N |
• no skeletal abnormalities are detected in newborn and 2 month-old mice
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• sperm count is increased compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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