Phenotypes associated with this allele

• Allele Symbol: Ptprv^tm1Kry
• Allele Name: targeted mutation 1, Gerard Karsenty
• Allele ID: MGI:3762914
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Amhr2^tm3(cre)Bhr/Amhr2^+ Ptprv^tm1Kry/Ptprv^tm1Kry	involves: 129S/SvEv	MGI:4949154
cn2	Bglap/Bglap2^tm1Kry/Bglap^+ Ptprv^tm1Kry/Ptprv^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: 129S7/SvEvBrd * FVB	MGI:3763094
cn3	Bglap/Bglap2^tm1Kry/Bglap2^+ Ptprv^tm1Kry/Ptprv^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: 129S7/SvEvBrd * FVB	MGI:3763095
cn4	Ptprv^tm1Kry/Ptprv^tm1Kry Tg(Col1a1-cre)1Kry/0	involves: FVB	MGI:3763086

Genotype
MGI:4949154

cn1

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺; Ptprv^tm1Kry/Ptprv^tm1Kry
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:170888 )

N • mice exhibit normal male normal reproductive morphology

Genotype
MGI:3763094

cn2

• Allelic Composition: Bglap/Bglap2^tm1Kry/Bglap⁺; Ptprv^tm1Kry/Ptprv^tm1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:126780 )

N • unlike in Ptprv^tm1Kry/ Ptprv^tm1Kry Tg(Col1a1-cre)1Kry mice, glucose homeostasis is normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:126780 )

N • unlike in Ptprv^tm1Kry/ Ptprv^tm1Kry Tg(Col1a1-cre)1Kry mice, beta-cell proliferation is normal

Genotype
MGI:3763095

cn3

• Allelic Composition: Bglap/Bglap2^tm1Kry/Bglap2⁺; Ptprv^tm1Kry/Ptprv^tm1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129S7/SvEvBrd * FVB

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:126780 )

N • unlike in Ptprv^tm1Kry/ Ptprv^tm1Kry Tg(Col1a1-cre)1Kry mice, beta-cell proliferation is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:126780 )

N • unlike in Ptprv^tm1Kry/ Ptprv^tm1Kry Tg(Col1a1-cre)1Kry mice, glucose homeostasis is normal

Genotype
MGI:3763086

cn4

• Allelic Composition: Ptprv^tm1Kry/Ptprv^tm1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: FVB

mortality/aging

postnatal lethality, incomplete penetrance ( J:126780 )

• up to 15% of mice die prior to weaning when born to heterozygous mothers and up to 35% die prior to weaning when born to homozygous mothers

homeostasis/metabolism

increased circulating testosterone level ( J:170888 )

decreased circulating free fatty acids level ( J:126780 )

• following an overnight fast, serum levels of free fatty acids are not increased as they are in wild-type mice

decreased circulating triglyceride level ( J:126780 )

increased energy expenditure ( J:126780 )

• energy expenditure is higher than in wild-type mice

• however, food intake is not increased

abnormal glucose homeostasis ( J:126780 )

• insulin-stimulated glucose uptake in muscle, brown and white fat, and liver is increased compared to in wild-type mice

increased insulin secretion ( J:126780 )

decreased circulating glucose level ( J:126780 )

• blood glucose level at birth prior to milk ingestion is reduced 3-fold or more compared to in wild-type mice

hypoglycemia ( J:126780 )

• adult mice have low blood glucose levels compared to wild-type mice

increased circulating insulin level ( J:126780 )

improved glucose tolerance ( J:126780 )

increased insulin sensitivity ( J:126780 )

increased circulating adiponectin level ( J:126780 )

• serum adiponectin levels are increased by 2-fold compared to in wild-type mice

adipose tissue

increased fat cell size ( J:126780 )

• although fewer adipocytes are present (37+/-5.1x10³ adipocytes compared to 93.2+/-10.7x10³ adipocytes in wild-type mice), adipocytes are larger than in wild-type mice

decreased gonadal fat pad weight ( J:126780 )

• mice have lighter gonadal fat pads compared to wild-type mice

• decreased fat is restricted to visceral fat

increased adipocyte glucose uptake ( J:126780 )

• white adipose glucose uptake, 31.7+/-8.2 nmol/g/min compared to 16.7+/-2.7 nmol/g/min in wild-type mice; brown adipose tissue, 3330+/-263 nmol/g/min compared to 2022+/-205 nmol/g/min in wild-type mice

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:126780 )

• beta cell proliferation is increased 60% to 300% in 5 day old and 1 month old mice with no increase in apoptosis

abnormal pancreatic islet morphology ( J:126780 )

• mice exhibit an increase in pancreas insulin content, the number of islet cells, the size of islet cells and the mass of beta cells

increased pancreatic beta cell mass ( J:126780 )

• beta cell mass is increased

increased pancreatic islet number ( J:126780 )

pancreatic islet hyperplasia ( J:126780 )

increased seminal vesicle weight ( J:170888 )

♂

increased insulin secretion ( J:126780 )

muscle

abnormal muscle fiber mitochondrial morphology ( J:126780 )

• mitochondrial area in muscle cells is increased compared to in wild-type cells

increased muscle cell glucose uptake ( J:126780 )

• insulin-stimulated glucose uptake in muscle is increased compared to in wild-type mice

• 358+/-65 nmol/g/min compared to 22+/-29 nmol/g/min in wild-type mice

cellular

increased adipocyte glucose uptake ( J:126780 )

• white adipose glucose uptake, 31.7+/-8.2 nmol/g/min compared to 16.7+/-2.7 nmol/g/min in wild-type mice; brown adipose tissue, 3330+/-263 nmol/g/min compared to 2022+/-205 nmol/g/min in wild-type mice

abnormal muscle fiber mitochondrial morphology ( J:126780 )

• mitochondrial area in muscle cells is increased compared to in wild-type cells

increased pancreatic beta cell proliferation ( J:126780 )

• beta cell proliferation is increased 60% to 300% in 5 day old and 1 month old mice with no increase in apoptosis

increased muscle cell glucose uptake ( J:126780 )

• insulin-stimulated glucose uptake in muscle is increased compared to in wild-type mice

• 358+/-65 nmol/g/min compared to 22+/-29 nmol/g/min in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:126780 )

N • despite an increase in mitochondrial area muscle mass over body mass ratio is normal

skeleton

skeleton phenotype ( J:126780 )

N • no skeletal abnormalities are detected in newborn and 2 month-old mice

reproductive system

increased seminal vesicle weight ( J:170888 )

♂

increased sperm number ( J:170888 )

♂ • sperm count is increased compared to in wild-type mice

increased epididymis weight ( J:170888 )

♂