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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cblbtm1Wlan
targeted mutation 1, Wallace Y Langdon
MGI:3762926
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cblbtm1Wlan/Cblbtm1Wlan involves: 129X1/SvJ * C57BL/6 MGI:3762927


Genotype
MGI:3762927
hm1
Allelic
Composition		 Cblbtm1Wlan/Cblbtm1Wlan
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Wlan mutation (0 available); any Cblb mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:126361 )
• slightly decreased rate of immunoglobulin receptor internalization
increased interleukin-6 secretion ( J:126361 )
• slightly enhanced levels produced by mast cells upon stimulation
increased tumor necrosis factor secretion ( J:126361 )
• slightly enhanced levels produced by mast cells upon stimulation

hematopoietic system
abnormal mast cell physiology ( J:126361 )
• slightly decreased rate of immunoglobulin receptor internalization




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory