Phenotypes associated with this allele

• Allele Symbol: Tg(Col1a1-Ptprv)1Kry
• Allele Name: transgene insertion 1, Gerard Karsenty
• Allele ID: MGI:3763103
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Col1a1-Ptprv)1Kry/?	Not Specified	MGI:3763104

Genotype
MGI:3763104

tg1

• Allelic Composition: Tg(Col1a1-Ptprv)1Kry/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased pancreatic beta cell proliferation ( J:126780 )

• mice exhibit decreased beta-cell proliferation

homeostasis/metabolism

abnormal glucose homeostasis ( J:126780 )

decreased insulin secretion ( J:126780 )

• mice exhibit impaired insulin secretion in response to glucose compared to wild-type mice

hyperglycemia ( J:126780 )

• when fed a normal diet

decreased circulating insulin level ( J:126780 )

• hypoinsulinemia

impaired glucose tolerance ( J:126780 )

• when fed a normal diet

insulin resistance ( J:126780 )

• when fed a normal diet

decreased adiponectin level ( J:126780 )

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:126780 )

• mice exhibit decreased beta-cell proliferation

decreased pancreatic beta cell mass ( J:126780 )

• mice exhibit lower beta-cell mass

decreased insulin secretion ( J:126780 )

• mice exhibit impaired insulin secretion in response to glucose compared to wild-type mice