Analysis Tools
mortality/aging
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• Background Sensitivity: when the allele is inherited paternally from a cross with a C57BL/6 female, mice display 50% lethality by week 2
• however, when the allele is inherited maternally mice are normal
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growth/size/body
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• Background Sensitivity: when the allele is inherited paternally from a cross with a 129 female, mice weigh 72% of wild-type mice
• Background Sensitivity: when the allele is inherited paternally from a cross with a C57BL/6 female, surviving mice are 75% of the size of wild-type mice
• however, when the allele is inherited maternally mice are normal
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cellular
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• imprinting and expression of Dlk1 and Gtl2 is altered depending of the parent of origin of the allele (paternal results in loss of Gtl2 imprinting while maternal results in lose of Dlk1 imprinting)
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