Analysis Tools
cellular
azoospermia
(
J:126511
)
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• no sperm are detected in the epididymis
• however, intratesticular testosterone levels are normal
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• only sporadic primary spermatocytes are observed
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mortality/aging
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• fewer than expected mice survive to weaning and beyond (6% compared to the expected 25%)
• increased mortality is associated with having a heterozygous mother
• however, survival can be improved by fostering mice to wild-type mothers
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• fewer than expected mice are born (17% compared to the expected 25%)
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reproductive system
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• ovaries contain only a few follicles
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• the full range of follicle stages is missing
• the maturation of follicles is arrested at the early secondary stage with most follicles missing oocytes
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small ovary
(
J:126511
)
|
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ovary cyst
(
J:126511
)
|
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• in extreme cases the ovary is displaced by one big cyst
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• testis weight is reduced to one forth of wild-type in all males
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• differentiated stages of spermatogenesis are absent
• with the exception of sporadic spermatocytes, no spermatozoa or other stages of spermatogenesis are found
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azoospermia
(
J:126511
)
|
|
• no sperm are detected in the epididymis
• however, intratesticular testosterone levels are normal
|
|
|
• only sporadic primary spermatocytes are observed
|
cardiovascular system
small heart
(
J:126511
)
|
• unlike other Gja1 deficient mice, only the size of the heart is smaller in neonates
• 95+/-24 mg compared to 121+/-26 mg for wild-type mice
• however, left-ventricular mass and ejection fraction are normal in neonates while heart rate and ejection volume are normal in adults
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• 300+/-70 beats per minute compared to 346+/-80 beats per minute in wild-type neonates
• however, there is no difference in electrocardiogram readings for neonates
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• infra-Hisian conduction is impaired (9.5+/-0.7 ms compared to 12.4+/-2.4 ms in wild-type mice)
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• hearts exhibit prolonged QRS (10.9+/-0.6 ms compared to 9.1+/-0.7 ms in wild-type hearts)
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• hearts exhibit shorter rate-corrected QTc-intervals (12.2+/-1.1 ms compared to 16.0+/-2.6 ms for wild-type hearts) in surface electrocardiogram
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growth/size/body
ovary cyst
(
J:126511
)
|
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• in extreme cases the ovary is displaced by one big cyst
|
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• mice weigh is reduced by 30% (20+/-2 g compared to 31+/-3 g for wild-type mice)
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endocrine/exocrine glands
|
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• ovaries contain only a few follicles
|
|
|
• the full range of follicle stages is missing
• the maturation of follicles is arrested at the early secondary stage with most follicles missing oocytes
|
small ovary
(
J:126511
)
|
|
|
ovary cyst
(
J:126511
)
|
|
• in extreme cases the ovary is displaced by one big cyst
|
|
|
• testis weight is reduced to one forth of wild-type in all males
|
