All Phenotypes Tg(Itgax-cre)1-1Reiz MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Itgax-cre)1-1Reiz
transgene insertion 1-1, Boris Reizis
MGI:3763248

Summary

32 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0	B6.Cg-Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz	MGI:3809643
cn2	Rptor^tm1Ahir/Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz/0	B6.Cg-Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz	MGI:5441610
cn3	Pld4^tm1.1Nemz/Pld4^tm1.1Nemz Tg(Itgax-cre)1-1Reiz/0	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:6452099
cn4	Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo Tg(Itgax-cre)1-1Reiz/0	involves: 129 * C57BL/6 * CBA	MGI:7448516
cn5	Il15ra^tm1Ama/Il15ra^tm2.1Ama Lyz2^tm1(cre)Ifo/0 Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	MGI:4417844
cn6	Myd88^tm1Defr/Myd88^tm1Defr Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA	MGI:5547520
cn7	Braf^tm1Mmcm/Braf^tm1Mmcm Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:6192275
cn8	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3763283
cn9	Cx3cr1^{tm3(Hbegf)Litt}/Cx3cr1^{tm3(Hbegf)Litt} Tg(Itgax-cre)1-1Reiz/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5570963
cn10	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5314240
cn11	Hmgb1^tm1.1Ttg/Hmgb1^tm1.1Ttg Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5563543
cn12	Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5545813
cn13	Lyn^tm1.1Calo/Lyn^tm1.1Calo Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5545814
cn14	Il6^tm1Kopf/Il6⁺ Prdm1^tm1Clme/Prdm1^tm1Clme Tg(Itgax-cre)1-1Reiz/0	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA	MGI:5515639
cn15	Prdm1^tm1Clme/Prdm1^tm1Clme Tg(Itgax-cre)1-1Reiz/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5515634
cn16	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(Itgax-cre)1-1Reiz/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5545809
cn17	Rab32^{tm1c(KOMP)Wtsi}/Rab32^{tm1c(KOMP)Wtsi} Tg(Itgax-cre)1-1Reiz/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA	MGI:6393530
cn18	Zranb1^{tm1c(EUCOMM)Hmgu}/Zranb1^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0	involves: 129S4/SvJaeSor * C57BL/6N * CBA	MGI:5897848
cn19	Il15ra^tm1Ama/Il15ra^tm2.1Ama Tg(Itgax-cre)1-1Reiz/0	involves: 129X1/SvJ * C57BL/6J * CBA	MGI:4417842
cn20	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Tg(Itgax-cre)1-1Reiz/0	involves: C3H * C57BL/6 * C57BL/6J	MGI:6196862
cn21	Pycard^tm1Ayaz/Pycard^tm1Ayaz Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5467386
cn22	Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5547518
cn23	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt Tg(Itgax-cre)1-1Reiz/0 Tg(Prnp)a20Cwe/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5903129
cn24	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:5903128
cn25	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/?	involves: C57BL/6 * C57BL/6N * CBA	MGI:5696542
cn26	Ddx41^tm1.1Arte/Ddx41^tm1.1Arte Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6N * CBA	MGI:6401463
cn27	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^{tm1c(EUCOMM)Hmgu}/Nfatc3^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6N * CBA	MGI:7623788
cn28	Sec22b^{tm1c(EUCOMM)Wtsi}/Sec22b^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6N * CBA * SJL	MGI:6156916
cn29	Ifnb1^tm2.1Lien/Ifnb1^tm2.1Lien Tg(Itgax-cre)1-1Reiz/0 Tyr^c-2J/Tyr^c-2J	involves: C57BL/6 * CBA	MGI:5007897
cn30	Id2^tm2.1Gtbz/Id2^tm2.1Gtbz Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * CBA	MGI:5486200
cn31	Extl1^em1Caox/Extl1^em1Caox Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * CBA	MGI:7641474
cn32	Rab7b^tm1Ciphe/Rab7b^tm1Ciphe Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6N * CBA	MGI:6888148

Allelic Composition	Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0
Genetic Background	B6.Cg-Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell differentiation ( J:139001 )

• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice

• maturation markers on DCs such as I-A^b, CD80, and CD86 have several fold lower expression than in controls

abnormal T-helper 1 cell differentiation ( J:139001 )

• less Th1 T cells develop when nave antigen-specific T cells are transferred into these mice with cognate antigen and a TLR9 agonist

decreased IgG1 level ( J:139001 )

• antigen specific IgG1 levels are lower by almost an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2b level ( J:139001 )

• antigen specific IgG2b levels are lower by an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2c level ( J:139001 )

• antigen specific IgG2c levels are lower by several orders of magnitude than controls after immunization with OVA-peptide and TLR9 agonist

abnormal NK cell physiology ( J:139001 )

• NK cells in vivo make much several fold less IFN-gamma in response to injections of TLR9 agonists

• there is also a reduction in IFN-gamma production upon LPS administration

decreased circulating interleukin-12b level ( J:139001 )

• mice fail to make IL-12p40 in response to the TLR9 agonist CpG-containing oligodeoxynucleotide ODN1826

• IL-12p40 production is reduced 5- to 30- fold in response to agonists to TLR1 +TLR2, TLR4, TLR5, TLR7, or TLR9

decreased circulating interleukin-6 level ( J:139001 )

• circulating levels of IL-6 one hour after TLR9 stimulation is half that in wild-type controls

abnormal dendritic cell physiology ( J:139001 )

• DCs fail to secrete cytokines in response to TLR9 agonists

abnormal dendritic cell antigen presentation ( J:139001 )

• nave antigen-specific T cells expand at a much slower rate when transferred into these mice with cognate antigen and TLR9 agonist

homeostasis/metabolism

decreased circulating interleukin-12b level ( J:139001 )

• mice fail to make IL-12p40 in response to the TLR9 agonist CpG-containing oligodeoxynucleotide ODN1826

• IL-12p40 production is reduced 5- to 30- fold in response to agonists to TLR1 +TLR2, TLR4, TLR5, TLR7, or TLR9

decreased circulating interleukin-6 level ( J:139001 )

• circulating levels of IL-6 one hour after TLR9 stimulation is half that in wild-type controls

hematopoietic system

abnormal dendritic cell differentiation ( J:139001 )

• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice

• maturation markers on DCs such as I-A^b, CD80, and CD86 have several fold lower expression than in controls

abnormal T-helper 1 cell differentiation ( J:139001 )

• less Th1 T cells develop when nave antigen-specific T cells are transferred into these mice with cognate antigen and a TLR9 agonist

decreased IgG1 level ( J:139001 )

• antigen specific IgG1 levels are lower by almost an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2b level ( J:139001 )

• antigen specific IgG2b levels are lower by an order of magnitude compared to controls after immunization with OVA-peptide and TLR9 agonist

decreased IgG2c level ( J:139001 )

• antigen specific IgG2c levels are lower by several orders of magnitude than controls after immunization with OVA-peptide and TLR9 agonist

abnormal NK cell physiology ( J:139001 )

• NK cells in vivo make much several fold less IFN-gamma in response to injections of TLR9 agonists

• there is also a reduction in IFN-gamma production upon LPS administration

cellular

abnormal dendritic cell differentiation ( J:139001 )

• dendritic cell maturation mediated by injections of TLR9 agonists is diminished in these mice

• maturation markers on DCs such as I-A^b, CD80, and CD86 have several fold lower expression than in controls

Allelic Composition	Rptor^tm1Ahir/Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz/0
Genetic Background	B6.Cg-Rptor^tm1Ahir Tg(Itgax-cre)1-1Reiz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rptor^tm1Ahir mutation (0 available); any Rptor mutation (117 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to induced colitis ( J:188676 )

• DSS-treated mice exhibit enhanced colitis with exaggerated body weight loss and reduction of colon length compared with control mice

increased dendritic cell number ( J:188676 )

• expanded CD8+ splenic and CD11c+CD11b+ intestinal conventional dendritic cells

• however, the total number of conventional and plasmacytoid dendritic cells is normal

digestive/alimentary system

decreased colon length ( J:188676 )

• exaggerated reduction of colon length in DSS-treated mice

increased susceptibility to induced colitis ( J:188676 )

• DSS-treated mice exhibit enhanced colitis with exaggerated body weight loss and reduction of colon length compared with control mice

growth/size/body

increased susceptibility to weight loss ( J:188676 )

• exaggerated in DSS-treated mice

hematopoietic system

increased dendritic cell number ( J:188676 )

• expanded CD8+ splenic and CD11c+CD11b+ intestinal conventional dendritic cells

• however, the total number of conventional and plasmacytoid dendritic cells is normal

Allelic Composition	Pld4^tm1.1Nemz/Pld4^tm1.1Nemz Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld4^tm1.1Nemz mutation (0 available); any Pld4 mutation (26 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal peritoneal macrophage morphology ( J:281205 )

• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

immune system

abnormal peritoneal macrophage morphology ( J:281205 )

• elevated expression of major histocompatibility complex (MHC) class II peptides on surface of resident peritoneal macrophages

Allelic Composition	Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfil3^tm1.2Kubo mutation (0 available); any Nfil3 mutation (32 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:334296 )

N	• normal cDC1 development

immune system

immune system phenotype ( J:334296 )

N	• normal cDC1 development

Allelic Composition	Il15ra^tm1Ama/Il15ra^tm2.1Ama Lyz2^tm1(cre)Ifo/0 Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15ra^tm1Ama mutation (1 available); any Il15ra mutation (39 available)
Il15ra^tm2.1Ama mutation (1 available); any Il15ra mutation (39 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK cell number ( J:155298 )

• about half the number of NK cells in the spleen, lymph node, liver, and lung

• but no decrease is seen in the bone marrow

decreased CD8-positive, alpha-beta T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

decreased memory T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

abnormal immune system physiology ( J:155298 )

• decrease in the numbers of adoptively transferred transgenic CD8+ T cells compared to controls by 30 days after immunization

hematopoietic system

decreased NK cell number ( J:155298 )

• about half the number of NK cells in the spleen, lymph node, liver, and lung

• but no decrease is seen in the bone marrow

decreased CD8-positive, alpha-beta T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

decreased memory T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

Allelic Composition	Myd88^tm1Defr/Myd88^tm1Defr Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tnip1^tm1.2Ama mutation (0 available); any Tnip1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:205446 )

N	• unlike Tnip1^tm1.1Ama/Tnip1^tm1.1Ama Tg(Itgax-cre)1-1Reiz hematopoietic stem cells used in transplantation experiments, hematopoietic stem cells do not alter susceptibility to IMQ-induced psoriasis

immune system

immune system phenotype ( J:205446 )

N	• unlike Tnip1^tm1.1Ama/Tnip1^tm1.1Ama Tg(Itgax-cre)1-1Reiz mice, mice exhibit normal spleen mass, myeloid cell numbers and activated T lymphocyte

Allelic Composition	Braf^tm1Mmcm/Braf^tm1Mmcm Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Mmcm mutation (3 available); any Braf mutation (60 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:211690 )

• decrease in lifespan

immune system

hepatosplenomegaly ( J:211690 )

• severe hepatosplenomegaly

increased dendritic cell number ( J:211690 )

• lesions are associated with massive increase of MHC II+CD11c+ dendritic cells

• expansion of blood circulating dendritic cell precursors and blood circulating dendritic cells

enlarged lymph nodes ( J:211690 )

granulomatous inflammation ( J:211690 )

• histiocytic infiltrates in the skin, liver, spleen, and lungs by 8 weeks of age, resulting in a broad destruction of tissue architecture by 16 weeks of age

• histiocytic lesions exhibit classical granulomatous organization, including multinucleated giant cell formation

• granuloma lesions contain massive CD11c+ langerin+ infiltrates, a large number of macrophages, NK cells, B cells, and T cells, with a specific accumulation of regulatory T cells

• local fibrotic response is seen within the granulomas and surrounding stroma

increased inflammatory response ( J:211690 )

• mice rapidly develop an aggressive Langerhans-cells histiocytosis-like disease with 100% penetrance

cytokine storm ( J:211690 )

• granuloma lesions are associated with an increase in several chemokines and cytokines (Ccl2, Ccl15, Il6, Il10, IFN-gamma, and TGF-beta) indicative of a local cytokine storm

hematopoietic system

hepatosplenomegaly ( J:211690 )

• severe hepatosplenomegaly

anemia ( J:211690 )

• severe anemia

increased dendritic cell number ( J:211690 )

• lesions are associated with massive increase of MHC II+CD11c+ dendritic cells

• expansion of blood circulating dendritic cell precursors and blood circulating dendritic cells

growth/size/body

hepatosplenomegaly ( J:211690 )

• severe hepatosplenomegaly

liver/biliary system

hepatosplenomegaly ( J:211690 )

• severe hepatosplenomegaly

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Langerhans-cell histiocytosis		DOID:2571	OMIM:246400 OMIM:604856	J:211690

Allelic Composition	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (193 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased dendritic cell number ( J:125869 )

• splenic dendritic cell (DC) population is decreased similarly to bone marrow deletion of Rbpj; ratio of CD8^-/CD8⁺ dendritic cells is significantly decreased, resulting from 3-fold decrease in numbers of CD8^- DCs with normal numbers of CD8⁺ DCs

• frequency of cytokine-secreting CD8^- DCs in cultured splenocytes is decreased 3-fold compared to controls whereas cytokine-secreting CD8⁺ DCs is unchanged

immune system

decreased dendritic cell number ( J:125869 )

• frequency of cytokine-secreting CD8^- DCs in cultured splenocytes is decreased 3-fold compared to controls whereas cytokine-secreting CD8⁺ DCs is unchanged

abnormal cytokine secretion ( J:125869 )

• in response to TLR activation, dendritic cell cytokine production is decreased compared to controls

Allelic Composition	Cx3cr1^{tm3(Hbegf)Litt}/Cx3cr1^{tm3(Hbegf)Litt} Tg(Itgax-cre)1-1Reiz/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^{tm3(Hbegf)Litt} mutation (1 available); any Cx3cr1 mutation (45 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:210086 )

• mice treated with diphtheria toxin (DTR) and infected with non-invasive Salmonella exhibit decreased bacterial titers in the mesenteric lymph nodes as compared to mice carrying Cx3cr1^tm3(DTR)Litt in the absence of cre recombinase

Allelic Composition	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:181715 )

N	• mice exhibit normal perinatal survival

immune system

immune system phenotype ( J:181715 )

N	• mice exhibit normal lymphatic vessels

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:181715 )

N	• mice do not exhibit edema

Allelic Composition	Hmgb1^tm1.1Ttg/Hmgb1^tm1.1Ttg Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb1^tm1.1Ttg mutation (0 available); any Hmgb1 mutation (17 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased circulating interleukin-1 beta level ( J:205499 )

• following lipopolysaccharide stimulation

increased circulating interleukin-18 level ( J:205499 )

• following lipopolysaccharide stimulation

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:205499 )

• following lipopolysaccharide stimulation

increased circulating interleukin-18 level ( J:205499 )

• following lipopolysaccharide stimulation

Allelic Composition	Lyn^tm1.1Calo/Lyn^tm1.1Calo Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1.1Calo mutation (0 available); any Lyn mutation (65 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lupus-like autoimmune disease in Lyn^tm1Sor/Lyn^tm1Sor and Lyn^tm1.1Calo/Lyn^tm1.1Calo Top2a^{Gt(PST14568)Mfgc}/0 mice

mortality/aging

premature death ( J:200745 )

• average survival time of 8 months

immune system

enlarged spleen ( J:200745 )

• severe splenomegaly starting at 6 months of age

• spleens are 16- and 7.9-fold larger than those in controls and mice homozygous for Lyn^tm1Sor, respectively

myeloid hyperplasia ( J:200745 )

• dramatic expansion of myeloid compartment in the spleen and lymph nodes

• myeloid proliferations occurs earlier than in mice homozygous for Lyn^tm1Sor

increased dendritic cell number ( J:200745 )

• increase in the numbers of CD11c^hi MHCII+ conventional DCs and CD11c^lo B220+ Ly6C+ plasmacytoid DCs in the spleen and lymph nodes over time

increased leukocyte cell number ( J:200745 )

• increased numbers of monocytes/macrophages in the spleen and lymph nodes at 4 months of age

increased granulocyte number ( J:200745 )

• in the spleen and lymph nodes at 4 months of age

increased plasma cell number ( J:200745 )

• increase in the number of CD19^lo/- CD138^hi plasma cells in the spleen

increased T cell number ( J:200745 )

• high numbers of CD44^hi CD62L^lo/- effector T cells and CD69+ T cells

increased activated T cell number ( J:200745 )

• in secondary lymphoid organs

increased monocyte cell number ( J:200745 )

• in the spleen and lymph nodes at 4 months of age

abnormal leukocyte physiology ( J:200745 )

• myeloid cells are hyperresponsive to LPS

abnormal T cell activation ( J:200745 )

• in secondary lymphoid organs

abnormal circulating cytokine level ( J:200745 )

• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age

• high levels of circulating B-cell activating factor

abnormal circulating chemokine level ( J:200745 )

• increased levels of a number of chemokines at 6 months of age

increased circulating interferon-gamma level ( J:200745 )

• at 6 months of age

increased circulating interleukin-1 beta level ( J:200745 )

• at 6 months of age

increased circulating interleukin-12 level ( J:200745 )

• at 6 months of age

increased circulating interleukin-17 level ( J:200745 )

• at 6 months of age

increased circulating interleukin-6 level ( J:200745 )

• at 6 months of age

increased circulating tumor necrosis factor level ( J:200745 )

• at 6 months of age

enlarged lymph nodes ( J:200745 )

• increase in lymph node size and cellularity as early as 4 months of age, mainly due to increased numbers of T cells myeloid cells and dendritic cells

lymph node hyperplasia ( J:200745 )

abnormal dendritic cell physiology ( J:200745 )

• following exposure to Brefeldin A and LPS, splenic dendritic cells produce high levels of inflammatory cytokines

• CD11c^hi DCs are hyperresponsive to cytokine stimulation

increased autoantibody level ( J:200745 )

• high levels of autoreactive antibodies in the serum

increased inflammatory response ( J:200745 )

• by 8 months of age, 60-70% of mice display severe leukocyte infiltration in the lungs, liver, and skin

liver inflammation ( J:200745 )

glomerulonephritis ( J:200745 )

• enlarged glomeruli and increased leukocyte infiltration indicative of glomerulonephritis at 6 months of age

• abundant leukocyte infiltration in the interstitial tissue at 6 months of age

lung inflammation ( J:200745 )

skin inflammation ( J:200745 )

integument

skin inflammation ( J:200745 )

skin lesions ( J:200745 )

• develop macroscopic skin lesions starting around 6 months of age

renal/urinary system

glomerulonephritis ( J:200745 )

• enlarged glomeruli and increased leukocyte infiltration indicative of glomerulonephritis at 6 months of age

• abundant leukocyte infiltration in the interstitial tissue at 6 months of age

renal glomerular immunoglobulin deposits ( J:200745 )

• deposition of C3 in the glomeruli

homeostasis/metabolism

abnormal circulating cytokine level ( J:200745 )

• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age

• high levels of circulating B-cell activating factor

abnormal circulating chemokine level ( J:200745 )

• increased levels of a number of chemokines at 6 months of age

increased circulating interferon-gamma level ( J:200745 )

• at 6 months of age

increased circulating interleukin-1 beta level ( J:200745 )

• at 6 months of age

increased circulating interleukin-12 level ( J:200745 )

• at 6 months of age

increased circulating interleukin-17 level ( J:200745 )

• at 6 months of age

increased circulating interleukin-6 level ( J:200745 )

• at 6 months of age

increased circulating tumor necrosis factor level ( J:200745 )

• at 6 months of age

liver/biliary system

liver inflammation ( J:200745 )

respiratory system

lung inflammation ( J:200745 )

hematopoietic system

enlarged spleen ( J:200745 )

• severe splenomegaly starting at 6 months of age

• spleens are 16- and 7.9-fold larger than those in controls and mice homozygous for Lyn^tm1Sor, respectively

myeloid hyperplasia ( J:200745 )

• dramatic expansion of myeloid compartment in the spleen and lymph nodes

• myeloid proliferations occurs earlier than in mice homozygous for Lyn^tm1Sor

increased dendritic cell number ( J:200745 )

• increase in the numbers of CD11c^hi MHCII+ conventional DCs and CD11c^lo B220+ Ly6C+ plasmacytoid DCs in the spleen and lymph nodes over time

increased leukocyte cell number ( J:200745 )

• increased numbers of monocytes/macrophages in the spleen and lymph nodes at 4 months of age

increased granulocyte number ( J:200745 )

• in the spleen and lymph nodes at 4 months of age

increased plasma cell number ( J:200745 )

• increase in the number of CD19^lo/- CD138^hi plasma cells in the spleen

increased T cell number ( J:200745 )

• high numbers of CD44^hi CD62L^lo/- effector T cells and CD69+ T cells

increased activated T cell number ( J:200745 )

• in secondary lymphoid organs

increased monocyte cell number ( J:200745 )

• in the spleen and lymph nodes at 4 months of age

abnormal leukocyte physiology ( J:200745 )

• myeloid cells are hyperresponsive to LPS

abnormal T cell activation ( J:200745 )

• in secondary lymphoid organs

growth/size/body

enlarged spleen ( J:200745 )

• severe splenomegaly starting at 6 months of age

• spleens are 16- and 7.9-fold larger than those in controls and mice homozygous for Lyn^tm1Sor, respectively

Allelic Composition	Lyn^tm1.1Calo/Lyn^tm1.1Calo Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyn^tm1.1Calo mutation (0 available); any Lyn mutation (65 available)
Myd88^tm1Defr mutation (4 available); any Myd88 mutation (52 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:200745 )

N	• inflammation seen in mutant mice wild-type for Myd88 is reversed and mice do not develop autoantibodies

renal/urinary system

renal/urinary system phenotype ( J:200745 )

N	• kidneys are of normal size and cellularity and show no signs of inflammation

Allelic Composition	Il6^tm1Kopf/Il6⁺ Prdm1^tm1Clme/Prdm1^tm1Clme Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6^tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Prdm1^tm1Clme mutation (1 available); any Prdm1 mutation (66 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:178876 )

• mice do not develop autoantibodies, they mount an antibody response indistinguishable from control mice to NP-CGG, dendritic cells express the same level of IL-6 as dendritic cells from control mice after LPS stimulation, and show normal levels of follicular T helper cells and germinal cells in the spleen

Allelic Composition	Prdm1^tm1Clme/Prdm1^tm1Clme Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm1^tm1Clme mutation (1 available); any Prdm1 mutation (66 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T follicular helper cell differentiation ( J:178876 )

• generation of follicular T helper cells cells is enhanced when mutant dendritic cells are cultured with naive T cells from control mice in the presence of differentiation factors, indicating increased differentiation of these cells

increased germinal center B cell number ( J:178876 )

• more spontaneous germinal center B cells

increased T follicular helper cell number ( J:178876 )

• increase in the percentage and number of follicular T helper cells

increased spleen germinal center number ( J:178876 )

• more germinal centers in the spleen

increased splenocyte number ( J:178876 )

• total number of splenocytes are increased in females but not males

abnormal immune system physiology ( J:178876 )

• enhanced immune response after NP-CGG immunization with an increased high-affinity anti-NP IgG response, an increase in the number of germinal center B cells, and an increase in the number of total germinal cells and antigen-specific germinal cells

abnormal germinal center B cell physiology ( J:178876 )

• enhanced germinal center response in young mice

increased immunoglobulin level ( J:178876 )

• total serum immunoglobulin levels are increased in females but not males

increased IgG level ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal CD4-positive, alpha-beta T cell physiology ( J:178876 )

• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

increased interleukin-6 secretion ( J:178876 )

• increase in production of IL-6 by splenic dendritic cells and by bone marrow derived dendritic cells after LPS stimulation in females but not males

increased autoantibody level ( J:178876 )

• females, but not males, develop autoantibodies as early as 4-5 months of age, including anti-nuclear antibodies, anti-double stranded dNA, and anti-ENA5, which are all IgG

increased anti-nuclear antigen antibody level ( J:178876 )

increased anti-double stranded DNA antibody level ( J:178876 )

• IgG2b is the major isotype of anti-dsDNA antibodies

kidney inflammation ( J:178876 )

• inflammatory infiltrates in 10 month old females

renal/urinary system

increased urine protein level ( J:178876 )

• proteinuria in 10 month old females

kidney inflammation ( J:178876 )

• inflammatory infiltrates in 10 month old females

abnormal kidney morphology ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal mesangial cell morphology ( J:178876 )

• mesangial cell proliferation in 10 month old females

hematopoietic system

abnormal T follicular helper cell differentiation ( J:178876 )

increased germinal center B cell number ( J:178876 )

• more spontaneous germinal center B cells

increased T follicular helper cell number ( J:178876 )

• increase in the percentage and number of follicular T helper cells

increased spleen germinal center number ( J:178876 )

• more germinal centers in the spleen

increased splenocyte number ( J:178876 )

• total number of splenocytes are increased in females but not males

abnormal germinal center B cell physiology ( J:178876 )

• enhanced germinal center response in young mice

increased immunoglobulin level ( J:178876 )

• total serum immunoglobulin levels are increased in females but not males

increased IgG level ( J:178876 )

• kidney deposition of IgG in 10 month old females

abnormal CD4-positive, alpha-beta T cell physiology ( J:178876 )

• increase in expression of ICOS in CD4+ T cells, indicating that mice have more activated CD4+ T cells than controls

homeostasis/metabolism

increased urine protein level ( J:178876 )

• proteinuria in 10 month old females

cellular

abnormal mesangial cell morphology ( J:178876 )

• mesangial cell proliferation in 10 month old females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:178876

Allelic Composition	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:187773 )

• bone marrow derived dendritic cells (BMDCs) cultured under hypoxic conditions (1% oxygen) show upregulation of maturation markers such as MHCII, CD86, with CD80 only slightly enhanced; control BMDCs grown in hypoxic conditions show similar enhanced maturation markers

• stimulation by LPS does not further enhance expression of maturation markers as it does in BMDCs grown under normoxic conditions

• production of Il12p70, Il10, Il6, and Il23 is decreased in mutant and control BMDCs under hypoxic conditions, with Il22 upregulated compared to normoxic cells; mutant and control BMDCs generated under hypoxic conditions produce less TNFalpha and Il-1beta than cells under normoxic conditions

abnormal leukocyte migration ( J:187773 )

• fewer mutant BMDCs generated under hypoxic conditions migrate toward CCL19 in a transwell chamber assay than control cells grown under hypoxic conditions; migration toward CXCL12 is not different from controls under hypoxic or normoxic conditions

• mutant BMDCs generated under hypoxic conditions injected into mouse footpads show reduced migration to popliteal lymph nodes compared to control BMDCs grown under hypoxic conditions; mutant and control BMDCs generated under normoxic conditions migrate equally well to draining lymph nodes while control cells generated under hypoxia display enhanced migration relative to control cells from normoxic cultures, indicating migration under under hypoxic conditons is dependent on Hif1a

abnormal dendritic cell number ( J:187773 )

• bone marrow dendritic cells (BMDCs) differentiated under hypoxic conditions display reduced growth (proliferation) compared to control cells grown in hypoxia or mutant and control cells grown under normoxic (21% oxygen) conditions

cellular

abnormal cell physiology ( J:187773 )

• reduced amounts of ATP are detected in lysates of mutant BMDCs cultured under hypoxic conditions compared to control cells under hypoxia suggesting an energy metabolism defect with Hif1a deletion

abnormal leukocyte migration ( J:187773 )

hematopoietic system

abnormal leukocyte migration ( J:187773 )

abnormal dendritic cell number ( J:187773 )

Allelic Composition	Rab32^{tm1c(KOMP)Wtsi}/Rab32^{tm1c(KOMP)Wtsi} Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab32^{tm1c(KOMP)Wtsi} mutation (0 available); any Rab32 mutation (16 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased colon length ( J:267497 )

• more severely shortened colon during dextran sodium sulfate (DSS)-induced colitis

increased susceptibility to induced colitis ( J:267497 )

• increased, and earlier onset of, weight loss after dextran sodium sulfate (DSS) administration

• increased incidence of diarrhea and rectal bleeding after DSS administration

• more severely shortened colon after DSS administration

• increased intestinal tissue damage after DSS administration

• increased bacterial load in mesenteric lymph node and colon after DSS administration

increased susceptibility to colitis induced morbidity/mortality ( J:267497 )

• after dextran sodium sulfate (DSS) administration

immune system

increased susceptibility to induced colitis ( J:267497 )

• increased, and earlier onset of, weight loss after dextran sodium sulfate (DSS) administration

• increased incidence of diarrhea and rectal bleeding after DSS administration

• more severely shortened colon after DSS administration

• increased intestinal tissue damage after DSS administration

• increased bacterial load in mesenteric lymph node and colon after DSS administration

increased susceptibility to colitis induced morbidity/mortality ( J:267497 )

• after dextran sodium sulfate (DSS) administration

increased neutrophil cell number ( J:267497 )

• increased Cd11b+ Ly6g+ neutrophil frequency during dextran sodium sulfate (DSS)-induced colitis

abnormal cytokine secretion ( J:267497 )

• increased expression of Il1a, Il1b, Il6, Cxcl1, Cxcl2, Csf3 during dextran sodium sulfate (DSS)-induced colitis

• normal expression of Il4, Il10, Il12, Il17, Tnfa, Gzma, Gzmb, Stat4, Gata3, Rorc, Foxp3 during DSS-induced colitis

increased susceptibility to bacterial infection ( J:231298 , J:267497 )

• increased pathogen load in liver and spleen after intravenous injection of L. monocytogenes (J:231298)

• increased bacterial load in mesenteric lymph node and colon during dextran sodium sulfate (DSS)-induced colitis (J:267497)

• normal bacterial load in spleen during DSS-induced colitis (J:267497)

hematopoietic system

hematopoietic system phenotype ( J:267497 )

N	• normal Cd3+, Cd4+ and Cd8+ T cells during dextran sodium sulfate (DSS)-induced colitis during dextran sodium sulfate (DSS)-induced colitis • normal Cd80, Cd86 and Mog expression in Cd11c+ bone marrow dendritic cells (BMDCs) during DSS-induced colitis

increased neutrophil cell number ( J:267497 )

• increased Cd11b+ Ly6g+ neutrophil frequency during dextran sodium sulfate (DSS)-induced colitis

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:267497 )

• after dextran sodium sulfate (DSS) administration

Allelic Composition	Zranb1^{tm1c(EUCOMM)Hmgu}/Zranb1^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * CBA
Cell Lines	HEPD0538_8_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Zranb1^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Zranb1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:235701 )

N	• mice exhibit normal dendritic cell development, migration and maturation

decreased T helper 1 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

decreased T-helper 17 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

abnormal dendritic cell physiology ( J:235701 )

• bone marrow-derived dendritic cells induce a 2- to 3-fold decrease in LPS-stimulated differentiation of CD4+ T cells into Th1 and Th17 cells

• however, induction of regulatory T cells is normal

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:235701 )

• mice treated with MOG(35-55) along with pertussis toxin exhibit delayed onset, decreased clinical score and reduced inflammation compared with wild-type mice

hematopoietic system

decreased T helper 1 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

decreased T-helper 17 cell number ( J:235701 )

• in the CNS and draining lymph nodes of mice treated with MOG(35-55) along with pertussis toxin

Allelic Composition	Il15ra^tm1Ama/Il15ra^tm2.1Ama Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: 129X1/SvJ * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal NK cell differentiation ( J:155298 )

• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow

• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow

decreased NK cell number ( J:155298 )

• about half the number of NK cells in the spleen, lymph node, liver, and lung

• but no decrease is seen in the bone marrow

abnormal T cell subpopulation ratio ( J:155298 )

• marked decrease in the ratio of CD62L^hi to CD62L^lo memory phenotype CD8+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

decreased memory T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

abnormal NK cell physiology ( J:155298 )

• decrease in proliferation of CD27+ CD11b+ cells

• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride

immune system

abnormal NK cell differentiation ( J:155298 )

• increase in immature CD11b+ CXCR3+ NK cells in spleen and bone marrow

• more mature KLRG-1+ CD11b+ NK cells are underrepresented in spleen and bone marrow

decreased NK cell number ( J:155298 )

• about half the number of NK cells in the spleen, lymph node, liver, and lung

• but no decrease is seen in the bone marrow

abnormal T cell subpopulation ratio ( J:155298 )

• marked decrease in the ratio of CD62L^hi to CD62L^lo memory phenotype CD8+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

decreased memory T cell number ( J:155298 )

• decrease in numbers of memory phenotype CD8+ T cells, particularly in lymph nodes, spleen, and blood

• marked decrease in the number of CD62L^hi memory phenotype CD8+ T cells

abnormal NK cell physiology ( J:155298 )

• decrease in proliferation of CD27+ CD11b+ cells

• decrease in activation of adoptively transferred wild-type NK cells in response to lipopolysaccaride

Allelic Composition	Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce}/Gt(ROSA)26Sor⁺ Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C3H * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(OVAL/fla,GFP)Vnce} mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:260047 )

• mice are runted

hematopoietic system

increased neutrophil cell number ( J:260047 )

• mice exhibit elevation of neutrophils in tissues

increased monocyte cell number ( J:260047 )

• mice exhibit elevation of monocytes in tissues

immune system

increased neutrophil cell number ( J:260047 )

• mice exhibit elevation of neutrophils in tissues

increased monocyte cell number ( J:260047 )

• mice exhibit elevation of monocytes in tissues

skeleton

skeleton phenotype ( J:260047 )

N	• mice do not develop joint swellings

Allelic Composition	Pycard^tm1Ayaz/Pycard^tm1Ayaz Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pycard^tm1Ayaz mutation (0 available); any Pycard mutation (15 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:191239 )

N	• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit normal skin tumor formation

Allelic Composition	Tnip1^tm1.2Ama/Tnip1^tm1.2Ama Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tnip1^tm1.2Ama mutation (0 available); any Tnip1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

enlarged spleen ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

abnormal leukocyte morphology ( J:205446 )

• increased CD11b+Gr1+ myeloid cells

increased plasmacytoid dendritic cell number ( J:205446 )

• slightly in the spleen

increased memory T cell number ( J:205446 )

• CD4+ and CD8+ memory T cells

enlarged lymph nodes ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

increased interleukin-12 secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

increased interleukin-23 secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

increased interleukin-6 secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

increased tumor necrosis factor secretion ( J:205446 )

• from bone marrow-derived dendritic cells stimulated with LPS

hematopoietic system

enlarged spleen ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

abnormal leukocyte morphology ( J:205446 )

• increased CD11b+Gr1+ myeloid cells

increased plasmacytoid dendritic cell number ( J:205446 )

• slightly in the spleen

increased memory T cell number ( J:205446 )

• CD4+ and CD8+ memory T cells

abnormal hematopoietic stem cell physiology ( J:205446 )

• hematopoietic stem cells transplanted into irradiated recipient mice exhibit increased susceptibility to IMQ-induced psoriasis compared with control cells

growth/size/body

enlarged spleen ( J:205446 )

• by 3 to 4 months with accumulation of myeloid and memory T cells

Allelic Composition	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt Tg(Itgax-cre)1-1Reiz/0 Tg(Prnp)a20Cwe/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5^tm1.1Namt mutation (0 available); any Cxcr5 mutation (28 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tg(Prnp)a20Cwe mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to prion infection ( J:241561 )

• following oral administration of scrapie prion proteins, mice exhibit reduced follicular cell-associated prion infectivity in the spleen compared with control mice

• however, accumulation of prions in medial lymph nodes is normal

Allelic Composition	Cxcr5^tm1.1Namt/Cxcr5^tm1.1Namt Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5^tm1.1Namt mutation (0 available); any Cxcr5 mutation (28 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:241561 )

N	• mice exhibit normal secondary lymphoid tissue formation

abnormal dendritic cell chemotaxis ( J:241561 )

• impaired chemotaxis toward CXCL13 in conventional dendritic cell

decreased follicular dendritic cell number ( J:241561 )

• marginal reduction in the follicle dendritic cells in the spleen

decreased susceptibility to prion infection ( J:241561 )

• following oral administration of scrapie prion proteins, mice exhibit reduced follicular dendritic cell-associated accumulation of prion protein in the spleen compared with control mice

• splenectomy before oral prion exposure does not alter susceptibility

• however, prion disease susceptibility is normal when infection is established directly within the CNS

cellular

abnormal dendritic cell chemotaxis ( J:241561 )

• impaired chemotaxis toward CXCL13 in conventional dendritic cell

hematopoietic system

abnormal dendritic cell chemotaxis ( J:241561 )

• impaired chemotaxis toward CXCL13 in conventional dendritic cell

Allelic Composition	Atg16l1^{tm1c(EUCOMM)Wtsi}/Atg16l1^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/?
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Atg16l1 mutation (44 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:221019 )

N	• normal up-regulation of expression of autophagy regulators in intestinal epithelia, the mesenchymal compartment, and in cecal patches after infection with Salmonella typhimurium as seen in controls

immune system

immune system phenotype ( J:221019 )

N	• normal cytokine response by intestinal epithelial cells to infection

Allelic Composition	Ddx41^tm1.1Arte/Ddx41^tm1.1Arte Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx41^tm1.1Arte mutation (0 available); any Ddx41 mutation (46 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:265023 )

N	• normal percentage dendritic cells (DCs) in peripheral blood • normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

immune system

immune system phenotype ( J:265023 )

N	• normal percentage dendritic cells (DCs) in peripheral blood • normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

increased susceptibility to Retroviridae infection ( J:265023 )

• lack of interferon beta surge in BMDCs from MLV (murine leukemia virus) or HIV-infected mice

• 5x higher virus titer in spleen 16 days after inoculation of newborn pups with MLV (murine leukemia virus)

• higher infection levels in draining lymph node after subcutaneous inoculation with MLV (murine leukemia virus)

• normal interferon beta surge in bone marrow-derived macrophages (BMDMs) from MLV (murine leukemia virus)-infected mice

Allelic Composition	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^{tm1c(EUCOMM)Hmgu}/Nfatc3^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2^tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)
Nfatc3^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Nfatc3 mutation (71 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-2 secretion ( J:346703 )

• significantly reduced BPI induced secretion by bone marrow derived cells

Allelic Composition	Sec22b^{tm1c(EUCOMM)Wtsi}/Sec22b^{tm1c(EUCOMM)Wtsi} Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec22b^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Sec22b mutation (15 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:255769 )

• development of dendritic cell (DC), myeloid cell, T cell and other lymphoid populations, and thymocyte differentiation and T cell activation state

• dendritic cell (DC) development, cytokine response to toll-like receptor (Tlr) stimulation, direct antigen presentation, and endocytic antigen uptake

• in vivo cross-presentation of soluble antigens

• in vitro cross-presentation of soluble or particulate antigens using splenic Cd11c+ DCs

Allelic Composition	Ifnb1^tm2.1Lien/Ifnb1^tm2.1Lien Tg(Itgax-cre)1-1Reiz/0 Tyr^c-2J/Tyr^c-2J
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1^tm2.1Lien mutation (0 available); any Ifnb1 mutation (21 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tyr^c-2J mutation (26 available); any Tyr mutation (379 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172226 )

N	• mice exhibit normal response to L. monocytogenes infection

Allelic Composition	Id2^tm2.1Gtbz/Id2^tm2.1Gtbz Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm2.1Gtbz mutation (0 available); any Id2 mutation (21 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:194760 )

N	• in reconstitution assays, bone marrow cells are able to generate CD8alpha+ dendritic cells

immune system

immune system phenotype ( J:194760 )

N	• in reconstitution assays, bone marrow cells are able to generate CD8alpha+ dendritic cells

Allelic Composition	Extl1^em1Caox/Extl1^em1Caox Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Extl1^em1Caox mutation (0 available); any Extl1 mutation (41 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:333437 )

• decreased survival time, increased lung bacterial load, and increased lung inflammation after E. coli infection

immune system

immune system phenotype ( J:333437 )

N	• frequencies of major immune cell subtypes are similar to controls in 6- to 8 week old mice

enlarged spleen ( J:333437 )

• at 7-10 months of age

decreased dendritic cell number ( J:333437 )

• decrease in the proportion of CD11c+ dendritic cells in the draining lymph nodes but not in the spleen

• no abnormalities are detected in the development from precursors or survival, maturation, or T cell stimulating capacity of dendritic cells

• decrease in the proportion of CCR7+ CD11c+ cDCs but not CCR7+ CD11c- cells in draining lymph nodes under steady state conditions or after DFNB stimulation

• decreased proportions of CD11c+ cDCs and CCR7+ cDCs in the spleen and draining lymph nodes at 7-10 months of age

• decrease in the proportion of migratory but not resident cDCs in draining lymph nodes at 7-10 months of age

increased B cell number ( J:333437 )

• increased frequency of CD19+ B cells in the spleen and draining lymph nodes at 7-10 months of age

decreased T helper 1 cell number ( J:333437 )

• decreased development at 7-10 months of age

increased T cell number ( J:333437 )

• increased frequency of CD3+ T cells in spleen and draining lymph nodes at 7-10 months of age

increased T-helper 17 cell number ( J:333437 )

• increased development of Th17 cells at 7-10 months of age

increased Ly6C high monocyte number ( J:333437 )

• increased frequency of Ly6c^hiCD11c^hi monocytes in the spleen and draining lymph nodes at 7-10 months of age

abnormal regulatory T cell morphology ( J:333437 )

• impaired development of CD25+ and FOXP3+ Treg cells in draining lymph nodes but not the spleen

• impaired development of CD25+ and FOXP3+ Treg cells at 7-10 months of age

increased immunoglobulin level ( J:333437 )

• at 7-10 months of age Ig levels are increased

increased IgG level ( J:333437 )

• kidney IgG deposits at 7-10 months of age

increased circulating interleukin-17 level ( J:333437 )

• increased IL17a level at 7-10 months of age

increased circulating interleukin-6 level ( J:333437 )

• at 7-10 months of age

increased circulating tumor necrosis factor level ( J:333437 )

• at 7-10 months of age

enlarged lymph nodes ( J:333437 )

• at 7-10 months of age

abnormal dendritic cell physiology ( J:333437 )

• reduced level of basal CCR7 surface expression

abnormal dendritic cell migration ( J:333437 )

• reduced migration towards draining lymph nodes

• however, proportion of CD103+ CD11b- cDC1 and CD103- CD11b+ cDC2 in peripheral lung tissue are similar to controls

abnormal dendritic cell chemotaxis ( J:333437 )

• reduced migratory capacity in response to the ligand CCR7 but not CCL2 or CCL8 in mature dendritic cells

increased interleukin-6 secretion ( J:333437 )

• increased IL6 production in LPS stimulated mature dendritic cells

increased susceptibility to autoimmune disorder ( J:333437 )

• spontaneous development of systemic autoimmune disorders in elderly mice (7-10 months of age)

decreased acute inflammation ( J:333437 )

• reduced ear swelling following induction by 2,4-dinitro-fluorobenzene (DFNB)

chronic inflammation ( J:333437 )

• enhanced inflammatory cell infiltration in multiple organs at 7-10 months of age

increased susceptibility to bacterial infection induced morbidity/mortality ( J:333437 )

• decreased survival time, increased lung bacterial load, and increased lung inflammation after E. coli infection

growth/size/body

decreased body weight ( J:333437 )

• at 7-10 months of age

enlarged spleen ( J:333437 )

• at 7-10 months of age

renal/urinary system

abnormal kidney morphology ( J:333437 )

• kidney IgG deposits at 7-10 months of age

homeostasis/metabolism

increased circulating interleukin-17 level ( J:333437 )

• increased IL17a level at 7-10 months of age

increased circulating interleukin-6 level ( J:333437 )

• at 7-10 months of age

increased circulating tumor necrosis factor level ( J:333437 )

• at 7-10 months of age

cellular

abnormal dendritic cell migration ( J:333437 )

• reduced migration towards draining lymph nodes

• however, proportion of CD103+ CD11b- cDC1 and CD103- CD11b+ cDC2 in peripheral lung tissue are similar to controls

abnormal dendritic cell chemotaxis ( J:333437 )

• reduced migratory capacity in response to the ligand CCR7 but not CCL2 or CCL8 in mature dendritic cells

hematopoietic system

abnormal dendritic cell migration ( J:333437 )

• reduced migration towards draining lymph nodes

• however, proportion of CD103+ CD11b- cDC1 and CD103- CD11b+ cDC2 in peripheral lung tissue are similar to controls

abnormal dendritic cell chemotaxis ( J:333437 )

• reduced migratory capacity in response to the ligand CCR7 but not CCL2 or CCL8 in mature dendritic cells

enlarged spleen ( J:333437 )

• at 7-10 months of age

decreased dendritic cell number ( J:333437 )

• decrease in the proportion of CD11c+ dendritic cells in the draining lymph nodes but not in the spleen

• no abnormalities are detected in the development from precursors or survival, maturation, or T cell stimulating capacity of dendritic cells

• decrease in the proportion of CCR7+ CD11c+ cDCs but not CCR7+ CD11c- cells in draining lymph nodes under steady state conditions or after DFNB stimulation

• decreased proportions of CD11c+ cDCs and CCR7+ cDCs in the spleen and draining lymph nodes at 7-10 months of age

• decrease in the proportion of migratory but not resident cDCs in draining lymph nodes at 7-10 months of age

increased B cell number ( J:333437 )

• increased frequency of CD19+ B cells in the spleen and draining lymph nodes at 7-10 months of age

decreased T helper 1 cell number ( J:333437 )

• decreased development at 7-10 months of age

increased T cell number ( J:333437 )

• increased frequency of CD3+ T cells in spleen and draining lymph nodes at 7-10 months of age

increased T-helper 17 cell number ( J:333437 )

• increased development of Th17 cells at 7-10 months of age

increased Ly6C high monocyte number ( J:333437 )

• increased frequency of Ly6c^hiCD11c^hi monocytes in the spleen and draining lymph nodes at 7-10 months of age

abnormal regulatory T cell morphology ( J:333437 )

• impaired development of CD25+ and FOXP3+ Treg cells in draining lymph nodes but not the spleen

• impaired development of CD25+ and FOXP3+ Treg cells at 7-10 months of age

increased immunoglobulin level ( J:333437 )

• at 7-10 months of age Ig levels are increased

increased IgG level ( J:333437 )

• kidney IgG deposits at 7-10 months of age

Allelic Composition	Rab7b^tm1Ciphe/Rab7b^tm1Ciphe Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab7b^tm1Ciphe mutation (0 available); any Rab7b mutation (20 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell migration ( J:321707 )

• decreased migration speed in LPS-exposed cells

hematopoietic system

abnormal dendritic cell migration ( J:321707 )

• decreased migration speed in LPS-exposed cells

cellular

abnormal lysosome morphology ( J:321707 )

• reduced number of small lysosomes per cell in LPS-exposed cells

abnormal dendritic cell migration ( J:321707 )

• decreased migration speed in LPS-exposed cells

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