Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-MT2A)15Pne
• Allele Name: transgene insertion 15, Paul N Epstein
• Allele ID: MGI:3763353
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-MT2A)15Pne/?	involves: FVB	MGI:3763355

Genotype
MGI:3763355

tg1

• Allelic Composition: Tg(Myh6-MT2A)15Pne/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:100354 , J:126583 )

N • the contractile force and rate of left atria paced by a stimulator at a fixed frequency of 4 Hz and a voltage of 1.5 times the threshold was normal for up to 4 hours after separation from the right atria (J:100354)

N • mice exhibit no cardiac abnormalities when fed a low-fat diet (J:126583)

abnormal heart morphology ( J:126583 )

• mice are resistant to cardiac damage caused by a high-fat diet

abnormal heart left ventricle morphology ( J:126583 )

• left ventricle end-systolic diameter fails to increase as in wild-type mice when fed a high-fat diet

decreased heart left ventricle weight ( J:126583 )

• left ventricle weight fails to increase as in wild-type mice when fed a high-fat diet

abnormal cardiovascular system physiology ( J:126583 )

• fraction shortening fails to decrease as in wild-type mice when fed a high-fat diet

abnormal myocardial fiber physiology ( J:126583 )

• mice are resistant to the alterations in cardiomyocyte contractile properties (resting cell length, peak shortening, maximal velocity of shortening, maximal velocity of re-lengthening, and time to 90% shortening) induced by a high-fat diet

homeostasis/metabolism

increased circulating insulin level ( J:126583 )

• when fed a high-fat diet plasma insulin levels are increased (7.01+/-0.92 ng/ml compared to 0.20+/-0.04 ng/ml when fed a low-fat diet)

• however, the increased plasma insulin levels are comparable to those in wild-type mice fed a high-fat diet

abnormal metabolism ( J:126583 )

• the amount of reactive oxygen species fails to increase as in wild-type mice when fed a high-fat diet

decreased physiological sensitivity to xenobiotic ( J:100354 )

• mice fail to exhibit doxorubicin-induced inotrophy

• however, doxorubicin-induced chronotropy is normal

growth/size/body

increased body weight ( J:126583 )

• when fed a high-fat diet body weight is increased (30.07+/-1.02 g compared to 27.06+/-0.47 g when fed a low fat diet)

• however, the increased body weight is comparable to that in wild-type mice fed a high-fat diet