Phenotypes associated with this allele

• Allele Symbol: Tead4^tm1.1Bnno
• Allele Name: targeted mutation 1.1, Andres Buonanno
• Allele ID: MGI:3763362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tead4^tm1.1Bnno/Tead4^tm1.1Bnno	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3763370

Genotype
MGI:3763370

hm1

• Allelic Composition: Tead4^tm1.1Bnno/Tead4^tm1.1Bnno
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:126338 )

• while embryos are present at E3.5 none are detected between E6.5 and E15.5

embryo

absent blastocoele ( J:126338 )

absent trophoblast giant cells ( J:126338 )

• trophoblast stem cells fail to form

• however, embryonic stem cell differentiation into the three primary tissue lineages occurs

abnormal morula morphology ( J:126338 )

• all morulae present at E3.5 are abnormal characterized by poorly formed blastomeres unevenly distributed within the zona pellucida and by the absence of the blastocoel cavity