Phenotypes associated with this allele

• Allele Symbol: Cxcl14^tm1Tha
• Allele Name: targeted mutation 1, Takahiko Hara
• Allele ID: MGI:3763373
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcl14^tm1Tha/Cxcl14^tm1Tha	involves: C57BL/6 * CBA	MGI:3764458

Genotype
MGI:3764458

hm1

• Allelic Composition: Cxcl14^tm1Tha/Cxcl14^tm1Tha
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:126841 )

• birth ratio of homozygous mice from heterozygous cross was lower than expected Mendelian frequency

prenatal lethality, incomplete penetrance ( J:126841 )

• birth ratio of homozygous mice from heterozygous cross was lower than expected Mendelian frequency

• adult homozygous mice were fertile and asymptomatic for severe disease

growth/size/body

decreased body weight ( J:126841 )

• under regular diet and high fat diet feeding conditions, the mean body weight of homozygous was less than control heterozygous

decreased body length ( J:126841 )

• mean nasal-anal length of high fat diet fed homozygous mutant mice was significantly shorter than heterozygous control

adipose tissue

decreased white adipose tissue amount ( J:126841 )

• peri-ovarian white adipose tissue mass in homozygous female was significantly reduced only under regular diet but not under high fat diet

• weight of total visceral and subcutaneous fat in the body of homozygous female under high fat diet were not statistically different from heterozygous control

increased fat cell size ( J:126841 )

• high fat diet feeding dependent hypertrophy of adipocytes in white adipose tissue of homozygous female

behavior/neurological

decreased food intake ( J:126841 )

• under regular diet feeding homozygous mice ate less than heterozygous control mice

liver/biliary system

decreased liver triglyceride level ( J:126841 )

• the concentration of triglyceride in the liver was decreased in high fat diet fed mice

• concentration of serum triglyceride and FFA were not significantly changed

decreased liver weight ( J:126841 )

• the dimensions and mass of the liver of homozygous female under high fat diet feeding was smaller

• weights of liver and kidney were comparable under regular diet

renal/urinary system

decreased kidney weight ( J:126841 )

• kidney mass of high fat diet fed homozygous was smaller

• weights of liver and kidney were comparable under regular diet

hematopoietic system

decreased macrophage cell number ( J:126841 )

• Mac1+ macrophages in peri-ovarian white adipose tissue of high fat diet fed in homozygous mice decreased compared to heterozygous control

• F4/80+ macrophages surrounding mature adipocytes was decreased in white adipose tissue from high fat diet fed in homozygous mice compared to heterozygous control

immune system

decreased macrophage cell number ( J:126841 )

• Mac1+ macrophages in peri-ovarian white adipose tissue of high fat diet fed in homozygous mice decreased compared to heterozygous control

• F4/80+ macrophages surrounding mature adipocytes was decreased in white adipose tissue from high fat diet fed in homozygous mice compared to heterozygous control

homeostasis/metabolism

decreased circulating glucose level ( J:126841 )

• fasting blood glucose level of regular diet fed homozygous mutant mice were slightly lower than control heterozygous mice

• under high fat diet feeding condition the difference was more pronounced

decreased circulating insulin level ( J:126841 )

• lower serum insulin concentration

decreased circulating cholesterol level ( J:126841 )

• in high fat diet fed mice

impaired glucose tolerance ( J:126841 )

• in high fat diet fed mice

improved glucose tolerance ( J:126841 )

• in regular fat diet fed mice

increased insulin sensitivity ( J:126841 )

• high fat diet fed homozygous mutant mice exhibited a stronger insulin response in IITT test

• under regular diet feeding conditions showed a marginally enhanced sensitivity to insulin

decreased liver triglyceride level ( J:126841 )

• the concentration of triglyceride in the liver was decreased in high fat diet fed mice

• concentration of serum triglyceride and FFA were not significantly changed