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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gabpatm1Agro
targeted mutation 1, Alan G Rosmarin
MGI:3763374
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gabpatm1Agro/Gabpatm1Agro involves: 129 MGI:3763382
cn2
 		Gabpatm1Agro/Gabpatm1Agro involves: 129 MGI:3763383


Genotype
MGI:3763382
hm1
Allelic
Composition		 Gabpatm1Agro/Gabpatm1Agro
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabpatm1Agro mutation (0 available); any Gabpa mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:126422 )
N
• embryos are born in expected Mendelian ratio with normal embryonic development




Genotype
MGI:3763383
cn2
Allelic
Composition		 Gabpatm1Agro/Gabpatm1Agro
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabpatm1Agro mutation (0 available); any Gabpa mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cell mass ( J:126422 )
• cre-transduced mouse embryonic fibroblasts are enlarged and have abnormally increased cytoplasm
abnormal cell cycle checkpoint function ( J:126422 )
• cre-transduced mouse embryonic fibroblasts exhibit a reduction of cells in S-phase (less than 5% compared to 33% of wild-type cells)
decreased fibroblast proliferation ( J:126422 )
• cre-transduced mouse embryonic fibroblasts fail to proliferate
• however, no increase in apoptosis is observed
decreased DNA replication ( J:126422 )
• cre-transduced mouse embryonic fibroblasts are unable to replicate their DNA or enter S-phase following serum stimulation
• however, RNA and protein synthesis is normal

homeostasis/metabolism
decreased DNA replication ( J:126422 )
• cre-transduced mouse embryonic fibroblasts are unable to replicate their DNA or enter S-phase following serum stimulation
• however, RNA and protein synthesis is normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory