Phenotypes associated with this allele

• Allele Symbol: Mir155^tm1.1Rsky
• Allele Name: targeted mutation 1.1, Klaus Rajewsky
• Allele ID: MGI:3763386
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir155^tm1.1Rsky/Mir155^tm1.1Rsky	B6.Cg-Mir155^tm1Rsky/J	MGI:5707223
hm2	Mir155^tm1.1Rsky/Mir155^tm1.1Rsky	involves: 129 * C57BL/6	MGI:3763429

Genotype
MGI:5707223

hm1

• Allelic Composition: Mir155^tm1.1Rsky/Mir155^tm1.1Rsky
• Genetic Background: B6.Cg-Mir155^tm1Rsky/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T-helper 17 cell differentiation ( J:226678 )

• impaired Th17 cell differentiation as determined by decreased number of IL17+ CD4+ T cells following in vitro stimulation under Th17 polarizing conditions

decreased T-helper 17 cell number ( J:226678 )

• reduced percentage of IL17+ CD4+ T cells following in vitro stimulation under Th17 polarizing conditions

decreased effector memory T-helper cell number ( J:226678 )

• fewer numbers of IFNG+ and IL17+ CD4+ T effector cells observed in brain following EAE induction as compared to controls and homozygous Socs1^tm1.1Ayr mice

decreased regulatory T cell number ( J:226678 )

• decreased numbers of CD4+ Foxp3+ T cells in thymus and spleen as compared to wild-type

abnormal T cell physiology ( J:226678 )

• reduced proliferation of splenic CD4+ T cells following restimulation with MOG_35-55 peptide

• phenotype is less severe than in homozygous Socs1^tm1.1Ayr mice

immune system

abnormal T-helper 17 cell differentiation ( J:226678 )

• impaired Th17 cell differentiation as determined by decreased number of IL17+ CD4+ T cells following in vitro stimulation under Th17 polarizing conditions

decreased T-helper 17 cell number ( J:226678 )

• reduced percentage of IL17+ CD4+ T cells following in vitro stimulation under Th17 polarizing conditions

decreased effector memory T-helper cell number ( J:226678 )

• fewer numbers of IFNG+ and IL17+ CD4+ T effector cells observed in brain following EAE induction as compared to controls and homozygous Socs1^tm1.1Ayr mice

decreased regulatory T cell number ( J:226678 )

• decreased numbers of CD4+ Foxp3+ T cells in thymus and spleen as compared to wild-type

abnormal T cell physiology ( J:226678 )

• reduced proliferation of splenic CD4+ T cells following restimulation with MOG_35-55 peptide

• phenotype is less severe than in homozygous Socs1^tm1.1Ayr mice

decreased interleukin-6 secretion ( J:226678 )

• dendritic cells produce less of the pro-inflammatory cytokine IL6 following LPS stimulation than controls and homozygous Socs1^tm1.1Ayr mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:226678 )

• attenuated EAE phenotype; phenotype is less severe than that observed in homozygous Socs1^tm1.1Ayr mice

• most severe phenotype is observed in wild type mice

Genotype
MGI:3763429

hm2

• Allelic Composition: Mir155^tm1.1Rsky/Mir155^tm1.1Rsky
• Genetic Background: involves: 129 * C57BL/6

immune system

decreased germinal center B cell number ( J:121084 )

• homozygous mice exhibit reduced numbers of germinal center B cells in gut-associated lymphoid tissue (GALT), including Peyer's patches and mesenteric lymph nodes

abnormal B cell physiology ( J:121084 )

abnormal germinal center B cell physiology ( J:121084 )

• B cells exhibit deficient cytokine production

abnormal T cell physiology ( J:121084 )

• T cells show a Th2 cytokine bias (increased Il4-producing and decreased IFNgamma-producing cell numbers) with a higher fraction of interleukin-10 producing cells

abnormal humoral immune response ( J:121084 )

• mice show impaired T cell-dependent antibody responses

abnormal cytokine secretion ( J:121084 )

• B cells exhibit deficient TNFalpha and lymphotoxin A (LT-a) cytokine production

hematopoietic system

decreased germinal center B cell number ( J:121084 )

• homozygous mice exhibit reduced numbers of germinal center B cells in gut-associated lymphoid tissue (GALT), including Peyer's patches and mesenteric lymph nodes

abnormal B cell physiology ( J:121084 )

abnormal germinal center B cell physiology ( J:121084 )

• B cells exhibit deficient cytokine production

abnormal T cell physiology ( J:121084 )

• T cells show a Th2 cytokine bias (increased Il4-producing and decreased IFNgamma-producing cell numbers) with a higher fraction of interleukin-10 producing cells