Phenotypes associated with this allele

• Allele Symbol: Mir150^tm1Rsky
• Allele Name: targeted mutation 1, Klaus Rajewsky
• Allele ID: MGI:3763431
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir150^tm1Rsky/Mir150^tm1Rsky	involves: C57BL/6	MGI:3764005

Genotype
MGI:3764005

hm1

• Allelic Composition: Mir150^tm1Rsky/Mir150^tm1Rsky
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-2 B cell number ( J:127234 )

• there is a 2-fold decrease in peritoneal B-2 B cell numbers

increased B-1 B cell number ( J:127234 )

• splenic B-1 cells are increased by 4-fold, whereas in the peritoneal cavity, there are 2-fold more B-1 B cell than in controls

increased IgA level ( J:127234 )

• a 9-fold increase in serum levels is seen

increased IgG1 level ( J:127234 )

• 3-fold increase in serum levels is seen

• upon immunization with a T-cell dependent antigen, mice produce 3-4 times more IgG1 antibodies than controls

increased IgG2b level ( J:127234 )

• 4-fold increase in serum levels is seen

increased IgM level ( J:127234 )

• 2-fold increase in serum level is seen

hematopoietic system

decreased B-2 B cell number ( J:127234 )

• there is a 2-fold decrease in peritoneal B-2 B cell numbers

increased B-1 B cell number ( J:127234 )

• splenic B-1 cells are increased by 4-fold, whereas in the peritoneal cavity, there are 2-fold more B-1 B cell than in controls

increased IgA level ( J:127234 )

• a 9-fold increase in serum levels is seen

increased IgG1 level ( J:127234 )

• 3-fold increase in serum levels is seen

• upon immunization with a T-cell dependent antigen, mice produce 3-4 times more IgG1 antibodies than controls

increased IgG2b level ( J:127234 )

• 4-fold increase in serum levels is seen

increased IgM level ( J:127234 )

• 2-fold increase in serum level is seen