Phenotypes associated with this allele

• Allele Symbol: Ptprb^tm1Gdy
• Allele Name: targeted mutation 1, George D Yancopoulos
• Allele ID: MGI:3763454
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprb^tm1Gdy/Ptprb^tm1Gdy	involves: 129 * C57BL/6	MGI:3763526

Genotype
MGI:3763526

hm1

• Allelic Composition: Ptprb^tm1Gdy/Ptprb^tm1Gdy
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Angiogenic defects in Ptprb^tm1Gdy/Ptprb^tm1Gdy mouse embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:125903 )

• embryos start dying at E9.5, with no surviving embryos recovered beyond E11

growth/size/body

enlarged heart ( J:125903 )

• at E9.5, the heart is similar in size compared to wild-type embryos despite the rest of the embryo being much smaller

decreased embryo size ( J:125903 )

• embryos at E9.0 are significantly smaller

cardiovascular system

abnormal vascular regression ( J:125903 )

• the cephalic plexus fails to remodel into a hierarchical branched network

abnormal cardinal vein morphology ( J:125903 )

• missing in some embryos, and if present are poorly defined with incomplete remodeling

enlarged heart ( J:125903 )

• at E9.5, the heart is similar in size compared to wild-type embryos despite the rest of the embryo being much smaller

embryo

embryonic growth arrest ( J:125903 )

• embryos fail to develop past the E9.0 stage based on forelimb development and somite number

decreased embryo size ( J:125903 )

• embryos at E9.0 are significantly smaller

pale yolk sac ( J:125903 )

• at E9.0, there are no visible blood-filled vessels and the surface appears dimpled

• at E9.5, the endoderm is pulling away from the mesoderm due to the presence of hyperfused blood vessels

abnormal vitelline vascular remodeling ( J:125903 )

• at E9.5, the primitive vascular plexus merges together to form hyperfused vessels

cellular

abnormal vascular regression ( J:125903 )

• the cephalic plexus fails to remodel into a hierarchical branched network