Phenotypes associated with this allele

• Allele Symbol: Dnmt1^tm2Jrc
• Allele Name: targeted mutation 2, J Richard Chaillet
• Allele ID: MGI:3763529
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnmt1^tm2Jrc/Dnmt1^tm2Jrc	involves: 129S1/Sv	MGI:3763532
cx2	Dmap1^tm1.2Jrc/Dmap1^tm1.2Jrc Dnmt1^tm2Jrc/Dnmt1^tm2Jrc	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:5013804
cx3	Dmap1^tm1.2Jrc/Dmap1^+ Dnmt1^tm2Jrc/Dnmt1^tm2Jrc	involves: 129S1/Sv * C57BL/6 * FVB/N * SJL	MGI:5013805

Genotype
MGI:3763532

hm1

• Allelic Composition: Dnmt1^tm2Jrc/Dnmt1^tm2Jrc
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:126389 )

• despite elevated methyltransferase activity, mice are viable, fertile, develop normally, and have normal DNA methylation patterns in the spleen

Genotype
MGI:5013804

cx2

• Allelic Composition: Dmap1^tm1.2Jrc/Dmap1^tm1.2Jrc; Dnmt1^tm2Jrc/Dnmt1^tm2Jrc
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:172814 )

• no 8 cell embryos are recovered

Genotype
MGI:5013805

cx3

• Allelic Composition: Dmap1^tm1.2Jrc/Dmap1⁺; Dnmt1^tm2Jrc/Dnmt1^tm2Jrc
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

reproductive system

transmission ratio distortion ( J:172814 )

• most wild-type progeny die mid-gestation

cellular

abnormal DNA methylation ( J:172814 )