Phenotypes associated with this allele

• Allele Symbol: Trhr^tm1Hzg
• Allele Name: targeted mutation 1, Hongkui Zeng
• Allele ID: MGI:3763533
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trhr^tm1Hzg/Trhr^tm1Hzg	involves: 129/Sv * 129S1/SvImJ	MGI:3763535

Genotype
MGI:3763535

hm1

• Allelic Composition: Trhr^tm1Hzg/Trhr^tm1Hzg
• Genetic Background: involves: 129/Sv * 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating thyroxine level ( J:125915 )

• 2.3+/- ug/dl compared to 4.1+/-0.5 ug/dl in wild-type mice

increased circulating glucose level ( J:125915 )

• fasting glucose is increased (102+/-8 mg/dl compared to 76+/-8 mg/dl in wild-type mice)

behavior/neurological

behavior/neurological phenotype ( J:125915 )

N • daily food intake, locomotor activity, thermal pain, sensorimotor gating and fear conditioning behaviors are normal

behavioral despair ( J:125915 )

• mice display increased depressive behavior such as decreased escape behavior and increased immobility

increased anxiety-related response ( J:125915 )

• mice display increased anxiety, as measured by lower percentage of open arm entries and total time spent in the open arms, in an elevated plus maze compared to wild-type mice

growth/size/body

growth/size/body region phenotype ( J:125915 )

N • adult body weight and body length are normal