Phenotypes associated with this allele

• Allele Symbol: Egfr^tm1Msi
• Allele Name: targeted mutation 1, Maria Sibilia
• Allele ID: MGI:3763534
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egfr^tm1Msi/Egfr^tm1Msi Tg(Mx1-cre)1Cgn/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3763539
cn2	Egfr^tm1Msi/Egfr^tm1Msi Tg(Alb1-cre)7Gsc/?	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3763538

Genotype
MGI:3763539

cn1

• Allelic Composition: Egfr^tm1Msi/Egfr^tm1Msi; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125912 )

• reduced survival (50% versus 70% WT littermate controls) after two thirds partial hepatectomy

liver/biliary system

delayed liver regeneration ( J:125912 )

• in mice treated with poly I/C (to drive Cre expression), there is a reduction in number of proliferating hepatocytes 36 to 48 hours after two-thirds partial hepatectomy (PH)

• 7 days after PH, the liver-to-body weight ratio is lower compared to control mice

• 15 days after PH, there are no significant differences in the liver-to-bodyweight ratio indicating that after the initial delay mutant livers can complete regeneration

immune system

increased circulating tumor necrosis factor level ( J:125912 )

• higher levels in the serum are observed 24 hours after PH

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:125912 )

• higher levels in the serum are observed 24 hours after PH

Genotype
MGI:3763538

cn2

• Allelic Composition: Egfr^tm1Msi/Egfr^tm1Msi; Tg(Alb1-cre)7Gsc/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125912 )

• reduced survival (40% versus 70% WT littermate controls) after two thirds partial hepatectomy

growth/size/body

slow postnatal weight gain ( J:125912 )

• mice gain weight at a slower rate compared to controls starting at six weeks of age

liver/biliary system

delayed liver regeneration ( J:125912 )

• reduction in number of proliferating cells 36 to 48 hours after two-thirds partial hepatectomy (PH)

• increase in number of proliferating cells 7 days after PH

• 7 days after PH, the liver-to-body weight ratio is lower compared to control mice

• 15 days after PH, there are no significant differences in the liver-to-body weight ratio

immune system

increased circulating tumor necrosis factor level ( J:125912 )

• five-fold increase in serum levels 24 hours after partial hepatectomy

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:125912 )

• five-fold increase in serum levels 24 hours after partial hepatectomy